NCT02147548 is a Phase 3 clinical trial of etifoxine in Healthy Volunteers, sponsored by Biocodex.

Who is sponsoring NCT02147548?

NCT02147548 is sponsored by Biocodex.

What drugs are being tested in NCT02147548?

Interventions in NCT02147548: etifoxine, lorazepam, Placebo.

What condition does NCT02147548 study?

NCT02147548 studies Healthy Volunteers.

Is NCT02147548 still recruiting?

NCT02147548 is currently completed. Last updated 26 July 2016.

Last reviewed 2016-07-26 · How we verify

NCT02147548

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of the Effects of Etifoxine 100 mg and Lorazepam 2 mg on Vigilance and Cognitive Functions in the Elderly. A Monocentric, Randomized, Cross-over, Double-blind Clinical Study Versus Placebo

Completed Phase 3 Last updated 26 July 2016

What this trial tests

Phase 3 trial testing etifoxine in Healthy Volunteers in 31 participants. Completed in 1 October 2015.

Timeline

1 December 2013

Primary endpoint
1 October 2015

1 October 2015

Quick facts

Lead sponsor	Biocodex
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	31
Start date	1 December 2013
Primary completion	1 October 2015
Estimated completion	1 October 2015
Sites	1 location across France

Drugs / interventions tested

etifoxine (ETIFOXINE) — full drug profile →
lorazepam (lorazepam) — full drug profile →
Placebo

Conditions studied

Healthy Volunteers — all drugs for Healthy Volunteers →

Sponsor

Biocodex — full company profile →

Who can join

Adults 65 to 75, any sex, with Healthy Volunteers. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Reaction time (RTI) of Cambridge Neuropsychological Test Automated Batteries (CANTAB)
Time frame: 2 hours after the study treatment intake

Sponsor's own description

The purpose of this study is to evaluate the effects of etifoxine (an anxiolytic) compared to lorazepam (a benzodiazepine anxiolytic) on vigilance and cognitive functions in the elderly.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.
Knezevic NN, Yekkirala A, Yaksh TL. · · 2017 · cited 24× · PMID 29049116 · DOI 10.1213/ane.0000000000002442

Verify or expand the search:

Other recruiting trials for Healthy Volunteers

Currently open trials in the same condition.

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Other Biocodex trials

Trials by the same sponsor.

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NCT07176832 — Bioavailability of Stiripentol After Single Oral Dose of Capsule vs Suspension in Healthy Subjects (STILIQ) · Phase 1 · completed
NCT06282614 — Performance and Safety of MUCOGYNE® Ovule as a Moisturizer · NA · terminated
NCT05913479 — Evaluation of the Efficacy and Safety of Mucogye® Gel as a Moisturizer · NA · completed
NCT05735951 — Pharmacokinetic Parameters of Stiripentol in Renal Impaired Patients and Matching Controls With Normal Renal Function · Phase 1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02147548 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Biocodex
Last refreshed: 26 July 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02147548.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing