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NCT01960998: ProsTel

Perioperative Post-Prostatectomy Incontinence Home Telehealth Program

Completed NA Results posted Last updated 9 August 2021
What this trial tests

NA trial testing Pelvic Floor Muscle Training in Urinary Incontinence in 245 participants. Completed in 30 September 2019.

Timeline
11 August 2014
Primary endpoint
30 September 2019
30 September 2019

Quick facts

Lead sponsorVA Office of Research and Development
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingsingle
Primary purposetreatment
Enrollment245
Start date11 August 2014
Primary completion30 September 2019
Estimated completion30 September 2019
Sites3 locations across United States

Drugs / interventions tested

Conditions studied

Sponsor

VA Office of Research and Development — full company profile →

Who can join

Eligibility, male only, with Urinary Incontinence or Prostate Cancer. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Time to Continence Primary · 6 months

Time to continence was based on the time point at which participants reported no urinary incontinence on the International Consultation on Incontinence (ICI) Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF). ICIQ-UI SF is one of a series of ICI questionnaires that have been meticulously developed and tested. The ICIQ-UI SF is a brief (4 items), reliable (Cronbach's alpha = 0.95), questionnaire that quantifies both symptom burden and impact of incontinence and has been validated in men and women. It was administered weekly during the 6 months after surgery. Scores range from 0-21; hig

GroupValue95% CI
Telehealth With Pelvic Floor Muscle TrainingNANA – NA
Telehealth Without Pelvic Floor Muscle TrainingNANA – NA
International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) Total Score Secondary · 6 months, 9 months, 12 months

International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form total score. Scores range from 0-21; higher scores indicate worse condition.

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training7.1± 4.3
Telehealth Without Pelvic Floor Muscle Training7.0± 4.4
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training6.2± 3.9
Telehealth Without Pelvic Floor Muscle Training6.7± 5.1
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training5.9± 4.1
Telehealth Without Pelvic Floor Muscle Training6.0± 4.7
Expanded Prostate Cancer Index Urinary Incontinence Subscale (EPIC-UI) Secondary · 6 months, 9 months, 12 months

This measure, validated as a stand-alone assessment, consists of 4 questions from the full Expanded Prostate Cancer Index (EPIC), a health-related quality of life assessment tool. The EPIC was developed based on advice from an expert panel and prostate cancer survivors, expanding the 20-item University of California - Los Angeles Prostate Cancer Index. Scores range from 0-100; higher scores indicate worse condition.

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training63.9± 22.1
Telehealth Without Pelvic Floor Muscle Training63.5± 24.1
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training67.7± 21.2
Telehealth Without Pelvic Floor Muscle Training65.1± 26.2
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training70.4± 20.4
Telehealth Without Pelvic Floor Muscle Training68.0± 25.3
Incontinence Impact Questionnaire - Short Form (IIQ-SF) Secondary · 6 months, 9 months, 12 months

This measure, validated in men with post-prostatectomy incontinence, measures the impact of incontinence on regular activities. It is a condition-specific quality of life measure that has been widely used in incontinence clinical trials. There are seven items. Response options are: "not at all," "slightly," "moderately," "greatly." Scores range from 0-100; higher scores indicate greater impact.

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training19.4± 22.4
Telehealth Without Pelvic Floor Muscle Training22.3± 24.1
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training15.2± 21.4
Telehealth Without Pelvic Floor Muscle Training19.3± 24.9
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training13.5± 20.7
Telehealth Without Pelvic Floor Muscle Training16.5± 23.7
International Prostate Symptom Scale - Quality of Life Question Secondary · 6 months, 9 months, 12 months

Validated single question: "If you were to spend the rest of your life with your urinary problem the way it is now, how would you feel about that?" Response options: delighted, pleased, mostly satisfied, mixed (about equally satisfied and dissatisfied), mostly dissatisfied, unhappy, terrible.

6 months Delighted/Pleased
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training21
Telehealth Without Pelvic Floor Muscle Training30
6 months Mostly satisfied
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training27
Telehealth Without Pelvic Floor Muscle Training21
6 months Mixed
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training27
Telehealth Without Pelvic Floor Muscle Training18
6 months Mostly dissatisfied
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training13
Telehealth Without Pelvic Floor Muscle Training11
6 months Unhappy/Terrible
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training14
Telehealth Without Pelvic Floor Muscle Training14
9 months Delighted/Pleased
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training36
Telehealth Without Pelvic Floor Muscle Training32
9 months Mostly satisfied
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training22
Telehealth Without Pelvic Floor Muscle Training27
9 months Mixed
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training20
Telehealth Without Pelvic Floor Muscle Training9
Patient Satisfaction Question (PSQ) Secondary · 6 months, 9 months, 12 months

Patient's rating of satisfaction (Completely satisfied, Somewhat satisfied, Not at all satisfied)

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training35
Telehealth Without Pelvic Floor Muscle Training48
Telehealth With Pelvic Floor Muscle Training61
Telehealth Without Pelvic Floor Muscle Training38
Telehealth With Pelvic Floor Muscle Training5
Telehealth Without Pelvic Floor Muscle Training8
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training44
Telehealth Without Pelvic Floor Muscle Training46
Telehealth With Pelvic Floor Muscle Training53
Telehealth Without Pelvic Floor Muscle Training37
Telehealth With Pelvic Floor Muscle Training4
Telehealth Without Pelvic Floor Muscle Training11
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training54
Telehealth Without Pelvic Floor Muscle Training50
Telehealth With Pelvic Floor Muscle Training42
Telehealth Without Pelvic Floor Muscle Training34
Telehealth With Pelvic Floor Muscle Training5
Telehealth Without Pelvic Floor Muscle Training10
Estimated Percent Improvement (EPI) Secondary · 6 months, 9 months, 12 months

Participant self-report of perceived percent improvement from 0% to 100%

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training69.6± 29.6
Telehealth Without Pelvic Floor Muscle Training65.1± 34.5
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training76.0± 26.2
Telehealth Without Pelvic Floor Muscle Training72.6± 31.8
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training77.4± 28.7
Telehealth Without Pelvic Floor Muscle Training75.7± 28.8
Global Perception of Improvement (GPI) Secondary · 6 months, 9 months, 12 months

Participant's global perception of their improvement (Much better, Better, About the same, Worse, Much worse)

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training39
Telehealth Without Pelvic Floor Muscle Training43
Telehealth With Pelvic Floor Muscle Training41
Telehealth Without Pelvic Floor Muscle Training29
Telehealth With Pelvic Floor Muscle Training15
Telehealth Without Pelvic Floor Muscle Training16
Telehealth With Pelvic Floor Muscle Training3
Telehealth Without Pelvic Floor Muscle Training2
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training41
Telehealth Without Pelvic Floor Muscle Training43
Telehealth With Pelvic Floor Muscle Training45
Telehealth Without Pelvic Floor Muscle Training29
Telehealth With Pelvic Floor Muscle Training9
Telehealth Without Pelvic Floor Muscle Training15
Telehealth With Pelvic Floor Muscle Training3
Telehealth Without Pelvic Floor Muscle Training4
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training51
Telehealth Without Pelvic Floor Muscle Training43
Telehealth With Pelvic Floor Muscle Training31
Telehealth Without Pelvic Floor Muscle Training25
Telehealth With Pelvic Floor Muscle Training12
Telehealth Without Pelvic Floor Muscle Training19
Telehealth With Pelvic Floor Muscle Training2
Telehealth Without Pelvic Floor Muscle Training3
How Disturbing is Urine Leakage Secondary · 6 months, 9 months, 12 months

Single quality of life question: "How disturbing is the urine leakage problem to you?" (not at all, somewhat, or extremely disturbing)

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training39
Telehealth Without Pelvic Floor Muscle Training41
Telehealth With Pelvic Floor Muscle Training54
Telehealth Without Pelvic Floor Muscle Training42
Telehealth With Pelvic Floor Muscle Training8
Telehealth Without Pelvic Floor Muscle Training11
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training42
Telehealth Without Pelvic Floor Muscle Training42
Telehealth With Pelvic Floor Muscle Training53
Telehealth Without Pelvic Floor Muscle Training45
Telehealth With Pelvic Floor Muscle Training6
Telehealth Without Pelvic Floor Muscle Training7
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training43
Telehealth Without Pelvic Floor Muscle Training49
Telehealth With Pelvic Floor Muscle Training51
Telehealth Without Pelvic Floor Muscle Training34
Telehealth With Pelvic Floor Muscle Training7
Telehealth Without Pelvic Floor Muscle Training11
Activity Restriction Secondary · 6 months, 9 months, 12 months

Single quality of life question: "How much does leakage of urine restrict your activities?" (not at all, some of the time, most of the time, all of the time).

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training57
Telehealth Without Pelvic Floor Muscle Training48
Telehealth With Pelvic Floor Muscle Training34
Telehealth Without Pelvic Floor Muscle Training34
Telehealth With Pelvic Floor Muscle Training4
Telehealth Without Pelvic Floor Muscle Training7
Telehealth With Pelvic Floor Muscle Training6
Telehealth Without Pelvic Floor Muscle Training5
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training70
Telehealth Without Pelvic Floor Muscle Training63
Telehealth With Pelvic Floor Muscle Training25
Telehealth Without Pelvic Floor Muscle Training23
Telehealth With Pelvic Floor Muscle Training1
Telehealth Without Pelvic Floor Muscle Training4
Telehealth With Pelvic Floor Muscle Training5
Telehealth Without Pelvic Floor Muscle Training4
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training74
Telehealth Without Pelvic Floor Muscle Training65
Telehealth With Pelvic Floor Muscle Training19
Telehealth Without Pelvic Floor Muscle Training17
Telehealth With Pelvic Floor Muscle Training4
Telehealth Without Pelvic Floor Muscle Training7
Telehealth With Pelvic Floor Muscle Training4
Telehealth Without Pelvic Floor Muscle Training5
Return to Work Secondary · 6 months, 9 months, 12 months

Single quality of life question: "Have you been able to return to work since your surgery?" (yes, no, retired or disabled)

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training63
Telehealth Without Pelvic Floor Muscle Training49
Telehealth With Pelvic Floor Muscle Training3
Telehealth Without Pelvic Floor Muscle Training5
Telehealth With Pelvic Floor Muscle Training1
Telehealth Without Pelvic Floor Muscle Training2
Telehealth With Pelvic Floor Muscle Training34
Telehealth Without Pelvic Floor Muscle Training38
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training62
Telehealth Without Pelvic Floor Muscle Training55
Telehealth With Pelvic Floor Muscle Training3
Telehealth Without Pelvic Floor Muscle Training2
Telehealth With Pelvic Floor Muscle Training1
Telehealth Without Pelvic Floor Muscle Training3
Telehealth With Pelvic Floor Muscle Training35
Telehealth Without Pelvic Floor Muscle Training34
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training66
Telehealth Without Pelvic Floor Muscle Training52
Telehealth With Pelvic Floor Muscle Training3
Telehealth Without Pelvic Floor Muscle Training4
Telehealth With Pelvic Floor Muscle Training1
Telehealth Without Pelvic Floor Muscle Training2
Telehealth With Pelvic Floor Muscle Training31
Telehealth Without Pelvic Floor Muscle Training36
Resumption of Normal Activity Secondary · 6 months, 9 months, 12 months

Single quality of life question: "Have you been able to resume your usual activities since your surgery?" (yes, no)

6 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training5
Telehealth Without Pelvic Floor Muscle Training7
Telehealth With Pelvic Floor Muscle Training23
Telehealth Without Pelvic Floor Muscle Training28
Telehealth With Pelvic Floor Muscle Training73
Telehealth Without Pelvic Floor Muscle Training59
9 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training4
Telehealth Without Pelvic Floor Muscle Training5
Telehealth With Pelvic Floor Muscle Training19
Telehealth Without Pelvic Floor Muscle Training19
Telehealth With Pelvic Floor Muscle Training78
Telehealth Without Pelvic Floor Muscle Training70
12 months
GroupValue95% CI
Telehealth With Pelvic Floor Muscle Training4
Telehealth Without Pelvic Floor Muscle Training3
Telehealth With Pelvic Floor Muscle Training16
Telehealth Without Pelvic Floor Muscle Training17
Telehealth With Pelvic Floor Muscle Training81
Telehealth Without Pelvic Floor Muscle Training74

Adverse events — posted to ClinicalTrials.gov

Time frame: 12 months. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Telehealth With Pelvic Floor Muscle Training
Serious: 0/101 (0%)
Deaths: 0/101
Telehealth Without Pelvic Floor Muscle Training
Serious: 1/96 (1%)
Deaths: 1/96

Serious adverse events (1 terms)

ReactionSystemTelehealth With Pelvic Flo…Telehealth Without Pelvic …
DeathGeneral disorders
Other adverse events (1 terms — click to expand)

ReactionSystemTelehealth With Pelvic Flo…Telehealth Without Pelvic …
Complications of surgerySurgical and medical procedures

Most-reported serious reactions: Death.

Data from ClinicalTrials.gov NCT01960998 adverse events section.

Sponsor's own description

Many men develop urine leakage after prostate cancer surgery. Usually it is temporary, but pelvic floor muscle training and exercise (including urine control strategies) have been shown to reduce the time to regaining urine control. This study tests an evidence-based, pelvic floor muscle training program that has been adapted to telehealth format and pilot tested in a VA-funded pilot/developmental trial. Training is begun 1-4 weeks before surgery and continued 6 months after surgery. Content is accessed on a secure website in daily 10-minute sessions which transition to weekly sessions for post-operative months 3-6. In the investigators' pilot study, Veterans reported that they appreciated receiving the training in the privacy of their homes, enjoyed the interactive style of the learning experience, and felt better prepared to deal with urine leakage and empowered with new knowledge and skills to help themselves. Content for both control and treatment groups includes general information about prostate cancer; perioperative care; wetness, odor and skin care management. The treatment group will ALSO receive pelvic floor muscle training and bladder control strategies. Outcomes are measured with brief validated questions administered by the telehealth platform, and again at 9 and 12 months by mailed questionnaire or the telehealth platform.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Telemedicine and the assessment of clinician time: a scoping review.
    Kidholm K, Jensen LK, Johansson M, Montori VM. · · 2023 · cited 16× · PMID 38099431 · DOI 10.1017/s0266462323002830

Verify or expand the search:

Other trials of Pelvic Floor Muscle Training

Trials testing the same drug.

Other recruiting trials for Urinary Incontinence

Currently open trials in the same condition.

Other VA Office of Research and Development trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01960998.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing