Last reviewed · How we verify

NCT01932710

A Feasibility Study of Prophylactic White Blood Cell Transfusions

Completed Phase 2 Last updated 12 January 2018
What this trial tests

Phase 2 trial testing White Blood Cell Transfusion in Leukemia in 45 participants. Completed in 30 November 2016.

Timeline
20 September 2013
Primary endpoint
30 November 2016
30 November 2016

Quick facts

Lead sponsorM.D. Anderson Cancer Center
PhasePhase 2
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposeprevention
Enrollment45
Start date20 September 2013
Primary completion30 November 2016
Estimated completion30 November 2016
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

M.D. Anderson Cancer Center — full company profile →

Who can join

Eligibility, any sex, with Leukemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with leukemia often have low white blood cell counts after chemotherapy, which puts them at greater risk of infection. The standard of care for preventing infections is to give these patients antibiotic, antifungal, and antiviral drugs during the time that white blood cell counts are low. However, many patients still develop infections during chemotherapy. Radiated white blood cell transfusions are a standard treatment once a patient develops a severe infection. The goal of this clinical research study is to learn if giving white blood cell transfusions that are not radiated early in chemotherapy might delay or prevent infections in patients with leukemia. Researchers also want to learn more about the type and severity of any infections that do occur.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction.
    Estcourt LJ, Stanworth SJ, Hopewell S, Doree C, et al · · 2016 · cited 43× · PMID 27128488 · DOI 10.1002/14651858.cd005339.pub2
  2. Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction.
    Estcourt LJ, Stanworth S, Doree C, Blanco P, et al · · 2015 · cited 30× · PMID 26118415 · DOI 10.1002/14651858.cd005341.pub3

Verify or expand the search:

Other recruiting trials for Leukemia

Currently open trials in the same condition.

Other M.D. Anderson Cancer Center trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01932710.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing