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NCT01916148
18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia
trial testing 18F-DOPA in Congenital Hyperinsulinism (CHI). Available.
Quick facts
| Lead sponsor | Children's Hospital of Philadelphia |
|---|---|
| Status | AVAILABLE |
| Study type | EXPANDED_ACCESS |
| Sites | 1 location across United States |
Drugs / interventions tested
- 18F-DOPA — full drug profile →
Conditions studied
- Congenital Hyperinsulinism (CHI) — all drugs for Congenital Hyperinsulinism (CHI) →
- Beckwith-Wiedemann Syndrome — all drugs for Beckwith-Wiedemann Syndrome →
- Insulinoma — all drugs for Insulinoma →
Sponsor
Children's Hospital of Philadelphia
Who can join
Eligibility, any sex, with Congenital Hyperinsulinism (CHI) or Beckwith-Wiedemann Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This purpose of this study is to determine the ability of an 18F-fluoro-L-dihydroxyphenylalanine (18F-DOPA) PET (Positron Emission Tomography) scan to detect a focal lesion of hyperinsulinism and determine the location in patients with congenital hyperinsulinism, Beckwith Wiedemann Syndrome and suspected insulinoma. Safety data will be collected.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Preclinical and Clinical Epigenetic-Based Reconsideration of Beckwith-Wiedemann Syndrome.
Papulino C, Chianese U, Nicoletti MM, Benedetti R, et al · · 2020 · cited 10× · PMID 33101381 · DOI 10.3389/fgene.2020.563718 -
Case Report: Two Distinct Focal Congenital Hyperinsulinism Lesions Resulting From Separate Genetic Events.
Rosenfeld E, Mitteer L, Boodhansingh K, Becker SA, et al · · 2021 · cited 8× · PMID 34336745 · DOI 10.3389/fped.2021.699129 -
Clinical Presentation and Outcomes of Insulinomas in Pediatric Patients.
Mitteer LM, Sanchez-Kleinberg Y, Lord K, Sigal W, et al · · 2026 · PMID 42149805 · DOI 10.1159/000552145
Verify or expand the search:
- PubMed search for NCT01916148
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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- NCT00001849 — New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome · Phase 2 · completed
Other Children's Hospital of Philadelphia trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01916148 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Hospital of Philadelphia
- Last refreshed: 2 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01916148.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing