NCT01683955 is a Phase 1 clinical trial of Tranexamic acid in Acute Blood Loss Anemia, sponsored by Henry Ford Health System.

Who is sponsoring NCT01683955?

NCT01683955 is sponsored by Henry Ford Health System.

What drugs are being tested in NCT01683955?

Interventions in NCT01683955: Tranexamic acid, Placebo.

What condition does NCT01683955 study?

NCT01683955 studies Acute Blood Loss Anemia, Osteoarthritis, Hip.

Is NCT01683955 still recruiting?

NCT01683955 is currently completed. Last updated 3 April 2023.

Last reviewed 2023-04-03 · How we verify

NCT01683955

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Topical Tranexamic Acid and Acute Blood Loss in Total Hip Arthroplasty

Completed Phase 1 Last updated 3 April 2023

What this trial tests

Phase 1 trial testing Tranexamic acid in Acute Blood Loss Anemia in 139 participants. Completed in 3 November 2013.

Timeline

1 January 2013

Primary endpoint
3 November 2013

3 November 2013

Quick facts

Lead sponsor	Henry Ford Health System
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	139
Start date	1 January 2013
Primary completion	3 November 2013
Estimated completion	3 November 2013
Sites	2 locations across United States

Drugs / interventions tested

Tranexamic acid (Tranexamic Acid) — full drug profile →
Placebo

Conditions studied

Acute Blood Loss Anemia — all drugs for Acute Blood Loss Anemia →
Osteoarthritis, Hip — all drugs for Osteoarthritis, Hip →

Sponsor

Henry Ford Health System — full company profile →

Who can join

18 and older, any sex, with Acute Blood Loss Anemia or Osteoarthritis, Hip. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to assess postoperative blood loss and transfusion rates in total hip replacement after one-time administration of topical tranexamic acid.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Topical application of tranexamic acid for the reduction of bleeding.
Ker K, Beecher D, Roberts I. · · 2013 · cited 85× · PMID 23881695 · DOI 10.1002/14651858.cd010562.pub2
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta-analysis.
Gibbs VN, Champaneria R, Sandercock J, Welton NJ, et al · · 2024 · cited 19× · PMID 38226724 · DOI 10.1002/14651858.cd013295.pub2
Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint replacement for hip, pelvic and long bone fractures.
Gibbs VN, Geneen LJ, Champaneria R, Raval P, et al · · 2023 · cited 16× · PMID 37272509 · DOI 10.1002/14651858.cd013499.pub2

Verify or expand the search:

Other trials of Tranexamic acid

Trials testing the same drug.

NCT07278037 — Trends in the Administration of Tranexamic Acid for Postpartum Hemorrhage · recruiting
NCT06599762 — Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia · Phase 2 · recruiting
NCT06657924 — Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery · Phase 2 · recruiting
NCT06806241 — Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery · recruiting
NCT06419075 — Tranexamic Acid in Vaginal Reconstructive Surgery · Phase 4 · withdrawn

Other recruiting trials for Acute Blood Loss Anemia

Currently open trials in the same condition.

NCT06606119 — The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma · recruiting
NCT05292001 — Single-dose Intravenous Iron Therapy for Anemia After Orthopaedic Trauma · Phase 4 · recruiting

Other Henry Ford Health System trials

Trials by the same sponsor.

NCT07450183 — Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1 · Phase 2 · not yet recruiting
NCT07418853 — Comparison of Goniotomy Device Outcomes in Combined Phacoemulsification-goniotomy Surgeries · NA · not yet recruiting
NCT06670287 — The Use of Multiple Sensors to Track Sleep in Nightshift Workers · NA · recruiting
NCT07363525 — Michigan Initial Experience Using Tigertriever for Thrombectomy · not yet recruiting
NCT07530172 — Radioembolization Versus External Radiation Therapy · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01683955 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Henry Ford Health System
Last refreshed: 3 April 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01683955.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing