NCT01589055 is a NA clinical trial of Intravenous Nicotine in Nicotine Dependence, sponsored by Mclean Hospital.

Who is sponsoring NCT01589055?

NCT01589055 is sponsored by Mclean Hospital.

What drugs are being tested in NCT01589055?

Interventions in NCT01589055: Intravenous Nicotine.

What condition does NCT01589055 study?

NCT01589055 studies Nicotine Dependence.

Is NCT01589055 still recruiting?

NCT01589055 is currently withdrawn. Last updated 15 January 2024.

Last reviewed 2024-01-15 · How we verify

NCT01589055

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior

Withdrawn NA Last updated 15 January 2024

What this trial tests

NA trial testing Intravenous Nicotine in Nicotine Dependence. Withdrawn.

Timeline

1 April 2005

Primary endpoint
1 December 2015

1 December 2015

Quick facts

Lead sponsor	Mclean Hospital
Phase	NA
Status	Withdrawn
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	other
Start date	1 April 2005
Primary completion	1 December 2015
Estimated completion	1 December 2015
Sites	1 location across United States

Drugs / interventions tested

Intravenous Nicotine — full drug profile →

Conditions studied

Nicotine Dependence — all drugs for Nicotine Dependence →

Sponsor

Mclean Hospital

Who can join

Adults 18 to 40, any sex, with Nicotine Dependence. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Effects of nicotine on hormones and mood states
Time frame: From baseline to study completion (approximately 4 months for males and 8 months for females)
We are examining the effects of IV nicotine on serum nicotine levels, serum/plasma hormone levels and nicotine-induced changes in subjective statues, as measured by a visual analog scale.

Sponsor's own description

Clinical studies are proposed to analyze the interactions between nicotine, alterations in endocrine hormones, mood and cardiovascular measures. The studies are designed to examine the contribution of gender and menstrual cycle phase. It is hypothesized that analysis of nicotine's rapid hormonal, cardiovascular and subjective effects will be important for developing novel biologic approaches to treatment for nicotine abuse and dependence as well as advancing understanding of the neurobiology of nicotine reinforcement.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Nicotine Dependence

Currently open trials in the same condition.

NCT07466875 — Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients · NA · recruiting
NCT07250230 — Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Un · NA · recruiting
NCT07040566 — A Trial of Varenicline for E-cigarette Cessation · Phase 2 · recruiting
NCT07001930 — Effects of Cannabidiol on Stress and Nicotine Withdrawal · Phase 1 · recruiting
NCT06765291 — Behavioral Intervention for Youth to Promote Vaping Cessation · NA · recruiting

Other Mclean Hospital trials

Trials by the same sponsor.

NCT07519759 — Recovery Inspired Support Engagement (RISE) Pilot · NA · not yet recruiting
NCT07503093 — Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis · NA · not yet recruiting
NCT07503067 — Identifying Substance Use Consequences · recruiting
NCT06816329 — Stress Dynamics and Familial Risk for Depression in Female Adolescents · NA · recruiting
NCT06876129 — Pharmacologic Augmentation of TMS for Depression With D-serine · Phase 1 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01589055 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mclean Hospital
Last refreshed: 15 January 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01589055.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing