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NCT01503632
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission
Phase 3 trial testing Behavioral Intervention in Acute Lymphoblastic Leukemia in 570 participants. Completed in 31 March 2026.
30 June 2019
Quick facts
| Lead sponsor | Children's Oncology Group |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 570 |
| Start date | 21 February 2012 |
| Primary completion | 30 June 2019 |
| Estimated completion | 31 March 2026 |
| Sites | 102 locations across Puerto Rico, United States |
Drugs / interventions tested
- Behavioral Intervention
- Compliance Monitoring
- Laboratory Biomarker Analysis — full drug profile →
- Mercaptopurine (MERCAPTOPURINE) — full drug profile →
- Questionnaire Administration
- Standard Follow-Up Care
Conditions studied
- Acute Lymphoblastic Leukemia — all drugs for Acute Lymphoblastic Leukemia →
Sponsor
Children's Oncology Group — full company profile →
Who can join
Adults 1 to 21, any sex, with Acute Lymphoblastic Leukemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized phase III trial studies compliance to a mercaptopurine treatment intervention compared to standard of care in younger patients with acute lymphoblastic leukemia that has had a decrease in or disappearance of signs and symptoms of cancer (remission). Assessing ways to help patients who have acute lymphoblastic leukemia to take their medications as prescribed may help them in taking their medications more consistently and may improve treatment outcomes.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Tumor microenvironment signaling and therapeutics in cancer progression.
Goenka A, Khan F, Verma B, Sinha P, et al · · 2023 · cited 203× · PMID 37005490 · DOI 10.1002/cac2.12416 -
Effect of a Daily Text Messaging and Directly Supervised Therapy Intervention on Oral Mercaptopurine Adherence in Children With Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Bhatia S, Hageman L, Chen Y, Wong FL, et al · · 2020 · cited 21× · PMID 32852553 · DOI 10.1001/jamanetworkopen.2020.14205 -
Nurse-Led Programs to Facilitate Enrollment to Children's Oncology Group Cancer Control Trials.
Haugen M, Kelly KP, Leonard M, Mills D, et al · · 2016 · cited 10× · PMID 26611754 · DOI 10.1177/1043454215617458 -
Adherence-enhancing intervention and relapse in childhood acute lymphoblastic leukemia: results from the Children's Oncology Group randomized trial ACCL1033.
Bhatia S, Hageman L, Chen Y, Wadhwa A, et al · · 2026 · PMID 41975001 · DOI 10.1038/s41375-026-02951-0
Verify or expand the search:
- PubMed search for NCT01503632
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Acute Lymphoblastic Leukemia
Currently open trials in the same condition.
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Other Children's Oncology Group trials
Trials by the same sponsor.
- NCT07412002 — Quality of End-of-Life Care for Children With Cancer · not yet recruiting
- NCT07498465 — A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After Hematopoietic Stem Cell Transplant · Phase 1 · withdrawn
- NCT07022678 — Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia · Phase 3 · not yet recruiting
- NCT07072585 — Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leuk · Phase 2, PHASE3 · not yet recruiting
- NCT06858501 — Comparing 123I-MIBG and 18F-MFBG Imaging in Patients With Newly Diagnosed, High Risk Neuroblastoma · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01503632 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Children's Oncology Group
- Last refreshed: 8 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01503632.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing