Who is sponsoring NCT01457053?

NCT01457053 is sponsored by University of Cincinnati.

What drugs are being tested in NCT01457053?

Interventions in NCT01457053: Loop diuretics (furosemide, torsemide, bumetanide), Ultrafiltration.

What condition does NCT01457053 study?

NCT01457053 studies Acute Decompensated Heart Failure.

Is NCT01457053 still recruiting?

NCT01457053 is currently terminated. Last updated 24 October 2016.

Are results published for NCT01457053?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2016-10-24 · How we verify

NCT01457053

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Randomized Controlled Pilot Study for Assessment of Coronary Flow Reserve With Cardiac PET Imaging in Acute Decompensated Heart Failure Patients Treated With Diuretics Versus Ultrafiltration

Terminated NA Results posted Last updated 24 October 2016

What this trial tests

NA trial testing Loop diuretics (furosemide, torsemide, bumetanide) in Acute Decompensated Heart Failure in 4 participants. Terminated before completion.

Timeline

1 November 2011

Primary endpoint
1 May 2013

1 May 2013

Quick facts

Lead sponsor	University of Cincinnati
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	diagnostic
Enrollment	4
Start date	1 November 2011
Primary completion	1 May 2013
Estimated completion	1 May 2013
Sites	2 locations across United States

Drugs / interventions tested

Loop diuretics (furosemide, torsemide, bumetanide) — full drug profile →
Ultrafiltration

Conditions studied

Acute Decompensated Heart Failure — all drugs for Acute Decompensated Heart Failure →

Sponsor

University of Cincinnati

Who can join

18 and older, any sex, with Acute Decompensated Heart Failure. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Myocardial Blood Flow
Time frame: 1 - 5 days
Evaluate the effects of ultrafiltration (UF) compared to intravenous diuretic therapy on myocardial blood flow (MBF) and coronary flow reserve (CFR), as assessed by positron emission tomography (PET), in patients with acutely decompensated heart failure (ADHF).

Sponsor's own description

The purpose of this research study is to compare the effects (good and bad) of ultrafiltration treatment with standard intravenous (in your vein) diuretic therapy (furosemide, torsemide, bumetanide) on your heart function and blood flow.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Ultrafiltration for acute heart failure.
Srivastava M, Harrison N, Caetano AFS, Tan AR, et al · · 2022 · cited 12× · PMID 35061249 · DOI 10.1002/14651858.cd013593.pub2

Verify or expand the search:

Other recruiting trials for Acute Decompensated Heart Failure

Currently open trials in the same condition.

NCT07372040 — Add-on Diuretics in Acute Decompensated Heart Failure · Phase 2 · recruiting
NCT07199088 — Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Ac · NA · recruiting
NCT03951467 — Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations · NA · recruiting
NCT06556810 — IC14 for Treatment of Acute Decompensated Heart Failure · Phase 1, PHASE2 · active not recruiting
NCT06714409 — Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure · NA · recruiting

Other University of Cincinnati trials

Trials by the same sponsor.

NCT05605366 — Minocycline In Neurocognitive Outcomes - Sickle Cell Disease · Phase 1 · not yet recruiting
NCT07528638 — Intraoperative Neuromonitoring (IONM) and Bipolar Electrocautery (BE) During Axillary Lymph Node Dissection (ALND) · NA · not yet recruiting
NCT07494890 — Measurement Properties of Mechanical Cost of Walking for Individuals With Walking Impairment · NA · recruiting
NCT07447895 — Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies · NA · not yet recruiting
NCT07231588 — Oral 5 Strain Probiotic for GI Toxicity Mitigation During Pelvic Radiation · EARLY_PHASE1 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01457053 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Cincinnati
Last refreshed: 24 October 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01457053.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing