NCT01177189 is a NA clinical trial of Vitamins C, E, and alpha lipoic acid in Aging, sponsored by VA Office of Research and Development.

Who is sponsoring NCT01177189?

NCT01177189 is sponsored by VA Office of Research and Development.

What drugs are being tested in NCT01177189?

Interventions in NCT01177189: Vitamins C, E, and alpha lipoic acid.

Is NCT01177189 still recruiting?

NCT01177189 is currently terminated. Last updated 21 February 2019.

Are results published for NCT01177189?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2019-02-21 · How we verify

NCT01177189

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Oxidative Stress Links Aging, Activity, and Mobility Limitation

Terminated NA Results posted Last updated 21 February 2019

What this trial tests

NA trial testing Vitamins C, E, and alpha lipoic acid in Aging in 87 participants. Terminated before completion.

Timeline

1 July 2011

Primary endpoint
3 July 2017

3 July 2017

Quick facts

Lead sponsor	VA Office of Research and Development
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	treatment
Enrollment	87
Start date	1 July 2011
Primary completion	3 July 2017
Estimated completion	3 July 2017

Drugs / interventions tested

Vitamins C, E, and alpha lipoic acid

Conditions studied

Aging — all drugs for Aging →

Sponsor

VA Office of Research and Development — full company profile →

Who can join

18 and older, any sex, with Aging. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Vascular Function (i.e. % Flow Mediated Vasodilation) Primary · 8 weeks

The effect on flow mediated vasodilation is measured using Doppler ultrasound.

Group	Value	95% CI
Arm 1	7.4	± 0.6
Arm 2	5.2	± 0.4

Exercise-induced Oxidative Stress (i.e. Free Radical Concentrations and Levels of Lipid Peroxidation) Secondary · 8 weeks

Free radicals and levels of lipid peroxidation were measured using electron paramagnetic spectroscopy and ELISA assays. A minimum value is 0 and a maximum value is 10. A higher value is a worse outcome.

Group	Value	95% CI
Arm 1	1.51	± 0.19
Arm 2	2.7	± 0.13

Vascular Function Following the Antioxidant Intervention Secondary · 8 weeks

The degree of vasodilation following the antioxidant intervention measured by Doppler ultrasound.

Group	Value	95% CI
Arm 1	5.8	± 0.6
Arm 2	8.2	± 0.6

Sponsor's own description

The purpose of this study is to understand why and how oxidative stress negatively impacts mobility in the elderly, and to determine whether antioxidant supplements can increase vascular health and mobility.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Aging

Currently open trials in the same condition.

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NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Other VA Office of Research and Development trials

Trials by the same sponsor.

NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT01177189 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
Last refreshed: 21 February 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01177189.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing