Adults 40 to 90, any sex, with Parkinson's Disease. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Dual Task Function #1Primary· baseline and 3 months
Dual task tested functional and cognitive performance while walking and talking simultaneously. Walking spatial and temporal parameters were measured using the Gaitrite 24 foot gaitmat with existing hardware and software for analysis.
Cycle time refers to the amount of time taken for a participant to complete a single stride. Lower scores indicate better outcomes. The range of scores for Cycle Time is: Pre (0.73-2.47), Post (0.72-1.45).
Cycle Time- baseline
Group
Value
95% CI
Arm 1: Treadmill Training
1.15
± 0.152
Arm 2: Memory Training
1.12
± .04
Arm 3: Treadmill and Memory Training
.987
± .037
Cycle Time- 3 months
Group
Value
95% CI
Arm 1: Treadmill Training
1.068
± .0375
Arm 2: Memory Training
1.09
± .052
Arm 3: Treadmill and Memory Training
.951
± .035
Dual Task Function #2Primary· baseline and 3 months
Dual task tested functional and cognitive performance while walking and talking simultaneously. Walking spatial and temporal parameters were measured using the Gaitrite 24 foot gaitmat with existing hardware and software for analysis.
Velocity was calculated by dividing the distance by the time it takes to travel that same distance, with consideration for direction. Higher values represent better outcomes. The range of scores for this study was: Pre (36.4 - 269.4), Post (76.3 - 267.6).
Velocity- baseline
Group
Value
95% CI
Arm 1: Treadmill Training
131.194
± 19.921
Arm 2: Memory Training
116.944
± 8.213
Arm 3: Treadmill and Memory Training
165.165
± 11.179
Velocity- 3 months
Group
Value
95% CI
Arm 1: Treadmill Training
134.7
± 9.016
Arm 2: Memory Training
127.353
± 10.177
Arm 3: Treadmill and Memory Training
174.581
± 12.985
Cognitive Function #1Primary· baseline and 3 months
2-Choice Reaction Time measures patients' ability to shift mental set. One of two stimuli are presented on the screen ("+ "or "\*"). Subjects press a specified response button on the keyboard corresponding to the presented stimulus. Units are "Throughput", which reflects efficiency of performance by being based on both accuracy and speed. Throughput represents correct responses/ minute.
Two Choice Reaction- baseline
Group
Value
95% CI
Arm 1: Treadmill Training
89.3535
± 6.939
Arm 2: Memory Training
93.413
± 6.227
Arm 3: Treadmill and Memory Training
101.236
± 4.588
Two Choice Reaction- 3 months
Group
Value
95% CI
Arm 1: Treadmill Training
105.677
± 7.278
Arm 2: Memory Training
103.4767
± 5.497
Arm 3: Treadmill and Memory Training
119.6465
± 5.117
Cognitive Function #2Primary· baseline and 3 months
The Stroop is a measure of selective attention and cognitive flexibility in which the subject must inhibit a preponderant response. Subjects are asked to complete three parts under timed conditions: (1) reading words describing colors written in black-and-white, (2) naming those colors when printed as X's, (3) naming the ink color when words describing the colors are mismatched with the colors (suppressing verbal content). Stroop interference scores from condition 3 are t-scores and higher scores equate with better outcomes.
Stroop- baseline
Group
Value
95% CI
Arm 1: Treadmill Training
48.37
± 1.278
Arm 2: Memory Training
41.74
± 2.581
Arm 3: Treadmill and Memory Training
48.4
± 1.54
Stroop- 3 months
Group
Value
95% CI
Arm 1: Treadmill Training
48.9
± 1.642
Arm 2: Memory Training
47.8
± 2.522
Arm 3: Treadmill and Memory Training
47.941
± 1.93
Timed Instrumental Activities of Daily Living (TIADL) Function #1Primary· baseline and 3 months
The Timed IADL involves the timing of performance of 5 tasks that mimic everyday instrumental activities of daily living: 1) finding a telephone number in the telephone directory, 2) counting out correct change from a group of coins, 3) finding then reading the ingredients on a food can label, 4) finding two food items in an array of food items (shopping), 5) finding then reading the directions on a medicine container. For each task there is a 2 minute time limit, with the exception of the telephone number task which has a limit of 3 mins. If the task is not completed within the time limit it
Timed IADL's Composite- baseline
Group
Value
95% CI
Arm 1: Treadmill Training
0.131
± 0.203
Arm 2: Memory Training
.234
± .164
Arm 3: Treadmill and Memory Training
-.2435
± 0.080
Timed IADL's Composite- 3 months
Group
Value
95% CI
Arm 1: Treadmill Training
0.075
± .370
Arm 2: Memory Training
.1928
± .13866
Arm 3: Treadmill and Memory Training
-.34
± 0.065
Timed Instrumental Activities of Daily Living (TIADL) Function #2Primary· baseline and 3 months
The Timed IADL for Shopping involved finding two food items in an array of food items. The task was timed in seconds and if completed with minor errors, a time penalty was added to the completion time. Higher scores/times meant worse performance. The range for shopping task completion was 0.61 to 69.9 seconds.
TIADL Shopping- baseline
Group
Value
95% CI
Arm 1: Treadmill Training
7.339
± 3.856
Arm 2: Memory Training
6.01
± 1.62
Arm 3: Treadmill and Memory Training
3.213
± 1.05
TIADL Shopping- 3 months
Group
Value
95% CI
Arm 1: Treadmill Training
3.493
± 0.980
Arm 2: Memory Training
4.746
± 1.346
Arm 3: Treadmill and Memory Training
2.39
± 0.591
Adverse events — posted to ClinicalTrials.gov
Time frame: Adverse events were collected during a 5 month subject participation period which included 1 month of baseline testing, 3 months of intervention, and 1 month of post-testing..
Reporting threshold: 0%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
This study compares the effects treadmill exercise, computerized cognitive training, or the combination of the two on executive function, dual-task performance, and performance on several Instrumental Activities of Daily Living (IADLs).
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
NCT07371338 — Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of IPS101A in Parkinson's Disease Patients
· Phase 1
· recruiting
NCT07330258 — A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite
· recruiting
NCT07384429 — Effects of Lemborexant on Motor-sleep Comorbidity in Parkinson's Disease
· Phase 4
· recruiting
NCT07384442 — Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's
· NA
· recruiting
NCT06562569 — Non-invasive VNS for PD Gait
· NA
· recruiting
Other VA Office of Research and Development trials
Trials by the same sponsor.
NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care
· Phase 1
· not yet recruiting
NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran
· NA
· not yet recruiting
NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness
· NA
· not yet recruiting
NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans
· NA
· not yet recruiting
NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges
· NA
· not yet recruiting
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
Last refreshed: 5 March 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01156714.