NCT00798122: SWAN

Study of Women With Acute Coronary Syndromes and Nonobstructive Coronary Artery Disease

Active, enrolled NA Last updated 2 July 2025

What this trial tests

NA trial testing Intravascular ultrasound in Acute Coronary Syndromes in 50 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 March 2006

Primary endpoint
6 September 2011

1 July 2027

Quick facts

Lead sponsor	NYU Langone Health
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	50
Start date	1 March 2006
Primary completion	6 September 2011
Estimated completion	1 July 2027
Sites	1 location across United States

Drugs / interventions tested

• Intravascular ultrasound
• MRI — full drug profile →

Conditions studied

• Acute Coronary Syndromes — all drugs for Acute Coronary Syndromes →

Sponsor

NYU Langone Health — full company profile →

Who can join

18 and older, female only, with Acute Coronary Syndromes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Approximately 600,000 women are treated for acute coronary syndrome (ACS) annually in the US. ACS includes heart attack and a milder form called unstable angina. Many of these women have angiograms of which 14-39% show no "significant" coronary artery disease (CAD, cholesterol plaque accumulation in arteries of the heart). The remaining majority of women with ACS have cholesterol plaque buildup which appears severe enough on angiography to limit blood flow to the heart.

It is difficult to advise women with heart attacks and no major heart artery blockages on what to do if chest pain happens again. Additional studies are needed to find out why this sort of heart attack happens and to help doctors understand how to treat patients who have this problem in the best possible way.

Some women with heart attacks who have no major blockage in heart arteries have cholesterol plaque in the arteries of the heart cannot be seen on angiography but can be seen using a newer technique called intravascular ultrasound (IVUS). IVUS involves creating pictures of the artery walls using ultrasound (sound waves) from within the artery itself. In some women without major heart artery blockage, heart attack is caused by low blood flow due to disease of smaller blood vessels which cannot be seen on angiography or IVUS. This problem can be found using magnetic resonance imaging (MRI), which can show blood flow to the heart. MRI may also be used to show where the heart has been damaged. The pattern of damage could suggest that a heart attack in a woman, who has no badly blocked heart arteries, happened for one (or more) of these reasons or another reason.

The Study of Women with ACS and Non-obstructive CAD (SWAN) will use IVUS and MRI to help determine the reasons for heart attacks in women with no major blockages in heart arteries.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease.
   Reynolds HR, Srichai MB, Iqbal SN, Slater JN, et al · · 2011 · cited 297× · PMID 21900087 · DOI 10.1161/circulationaha.111.026542