NCT00780299: Hyperdia

Hemodynamic Efficiency of an Hemodialysis Treatment With High Permeability in Post-resuscitation Shock

Completed Phase 3 Last updated 8 September 2025

What this trial tests

Phase 3 trial testing hemodialysis with high permeability (HDHP) in Cardiac Arrest in 38 participants. Completed in 2 January 2016.

Timeline

2 November 2008

Primary endpoint
2 January 2016

2 January 2016

Quick facts

Lead sponsor	Assistance Publique - Hôpitaux de Paris
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	38
Start date	2 November 2008
Primary completion	2 January 2016
Estimated completion	2 January 2016
Sites	1 location across France

Drugs / interventions tested

• hemodialysis with high permeability (HDHP)
• CVVH

Conditions studied

• Cardiac Arrest — all drugs for Cardiac Arrest →
• Sudden Cardiac Death — all drugs for Sudden Cardiac Death →
• Shock — all drugs for Shock →

Sponsor

Assistance Publique - Hôpitaux de Paris — full company profile →

Who can join

18 and older, any sex, with Cardiac Arrest or Sudden Cardiac Death. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Rationale: Despite spontaneous cardiac activity recovery, a shock occurs in more than half of patients after resuscitation for cardiac arrest. This acute circulatory insufficiency presents similar characteristics with septic shock and is responsible of most early deaths. Most frequently, usual treatments are unable to control this shock and to avoid the appearance of multiple organ failure.

Aim of the study: In addition to conventional therapeutics, an early plasma epuration of inflammatory mediators (HDHP) could be able to improve hemodynamic parameters and to reduce the shock duration. This improvement could have an impact on multiple organ dysfunctions and also on early mortality.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Hemodynamic efficiency of hemodialysis treatment with high cut-off membrane during the early period of post-resuscitation shock: The HYPERDIA trial.
   Geri G, Grimaldi D, Seguin T, Lamhaut L, et al · · 2019 · cited 18× · PMID 30974188 · DOI 10.1016/j.resuscitation.2019.03.045
2. ESICM LIVES 2018 : Paris, France. 20-24 October 2018.
   · 2018 · cited 16× · PMID 30341496 · DOI 10.1186/s40635-018-0201-6
3. Proceedings of Réanimation 2018, the French Intensive Care Society International Congress.
   · 2018 · cited 6× · PMID 29404789 · DOI 10.1186/s13613-017-0345-7