NCT00748995

Neuropsychological and Mental Outcomes of Operation Iraqi Freedom (OIF): A Longitudinal Cohort Study

Active, enrolled Last updated 9 October 2025

What this trial tests

trial in Stress Disorders, Post-Traumatic in 817 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

31 August 2010

Primary endpoint
10 July 2014

30 September 2026

Quick facts

Lead sponsor	VA Office of Research and Development
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	817
Start date	31 August 2010
Primary completion	10 July 2014
Estimated completion	30 September 2026
Sites	4 locations across United States

Conditions studied

• Stress Disorders, Post-Traumatic — all drugs for Stress Disorders, Post-Traumatic →

Sponsor

VA Office of Research and Development — full company profile →

Who can join

18 and older, any sex, with Stress Disorders, Post-Traumatic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a research study examining health effects of the Iraq War, especially those effects involving mental health. This study is a follow-up to the Neurocognition Deployment Health Study (NDHS), also called "Prospective Assessment of Neurocognition in Future Gulf-deployed and Gulf-nondeployed Military Personnel: A Pilot Study." The specific purpose of this research study is to find out more about the longer lasting effects of war on mood and stress symptoms, thinking and reaction skills, and different aspects of day to day life, such as work and daily activities. Survey and test results from previous participation in the NDHS will be compared to the new information that will be obtained from participants as part of this study. The investigators expect that a total of about 817 military personnel and military Veterans will participate in the study. There are two parts to this study: (1) mail/internet/phone survey and (2) in-person assessment. The investigators will invite all NDHS participants who deployed to Iraq to participate in the survey component. The survey component of the study involves being interviewed by phone about mood and stress symptoms and head injuries and completing written survey questions by either mail or on the internet that address basic personal history (such as age, military status, gender, combat injury history), mood, stress symptoms, and stressful experiences. The phone interview will take about 2 to 2.5 hours to complete. The questionnaire part will take about 20 to 30 minutes to complete, and can be completed either by mailing back completed questionnaires or by internet using a private, individual log-in/password combination. The investigators will invite approximately 200 selected at random from the larger group of survey responders to take part in the in-person assessment. The in-person assessment involves taking a small subset of neuropsychological tasks. The tasks will be given on a computer or using paper and pencil. Participants will also be asked to complete questionnaires about work, daily activities, and health history, as well as basic health measures such as height, weight, blood pressure, heart rate, and waist size. Potential participants will be given the option of completing the in-person assessment at one of the two study sites (Seattle or Boston), or in a private setting in their community (e.g., a hotel small conference room). Altogether, this part of the study will take about 120 minutes to 140 minutes to complete.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Early Predictors of Chronic PTSD Symptom Trajectories in US Army Soldiers Deployed to the Iraq War
   Vasterling JJ, Franz MR, Lee LO, Kaiser AP, et al · · 2022 · DOI 10.21203/rs.3.rs-2244497/v1