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NCT00689585
A Single Centre. Parallel-Group, Double-Blinded, Randomized, Placebo-Controlled Pilot Clinical Trial on Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS)
Phase 2 trial testing Placebo in Complex Regional Pain Syndromes in 4 participants. Terminated before completion.
1 July 2010
Quick facts
| Lead sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
|---|---|
| Phase | Phase 2 |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 4 |
| Start date | 1 September 2008 |
| Primary completion | 1 July 2010 |
| Estimated completion | 1 July 2010 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Placebo
- Ethosuximide (Ethosuximide) — full drug profile →
Conditions studied
- Complex Regional Pain Syndromes — all drugs for Complex Regional Pain Syndromes →
Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Who can join
18 and older, any sex, with Complex Regional Pain Syndromes. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Maximum tolerated dose (500mg-1500mg per day) and Safety profile
Time frame: up to 10 weeks
Primary outcomes will consist of the dose attained during the study and the safety (adverse event) profile. Maximum timeframe on study drug is 6 weeks. Adverse events will be collected up to one month after the trial period ends.
Sponsor's own description
Pain remains the most debilitating symptom for adult patients suffering from complex regional pain syndrome (CRPS). Most CRPS patients gain little to no relief from current painkillers. The purpose of this study is to evaluate the efficacy and safety of ethosuximide in search of much-needed adjunctive therapy to relieve the pain and suffering associated with CRPS.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT00689585
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ethosuximide
Trials testing the same drug.
- NCT04431778 — Evaluation of the Efficacy and Tolerance of Low Doses of Ethosuximide in the Treatment of Peripheral Neuropathic Pain · Phase 2 · unknown
- NCT03887624 — Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression. · EARLY_PHASE1 · completed
Other recruiting trials for Complex Regional Pain Syndromes
Currently open trials in the same condition.
- NCT05986461 — Spatially Transcriptomics Reveals Molecular Signatures in CRPS · recruiting
- NCT05814497 — Supraspinal Processing of Sensory Aspects of Pain · NA · recruiting
- NCT05593237 — Transcranial Magnetic Stimulation for Chronic Neuropathic Pain · NA · active not recruiting
- NCT05337501 — Prognostic Factors for Complex Regional Pain Syndrome · NA · active not recruiting
- NCT04144972 — Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain · NA · recruiting
Other McGill University Health Centre/Research Institute of the McGill University Health Centre trials
Trials by the same sponsor.
- NCT07439406 — Comparing Standard and Autoclaved Peanut Oral Immunotherapy in People With Peanut Allergy · Phase 2 · not yet recruiting
- NCT07328971 — Vancomycin Taper to Prevent Recurrent Clostridioides Difficile · Phase 3 · not yet recruiting
- NCT07556952 — Dex & Mastectomy Pain · Phase 4 · recruiting
- NCT07069582 — Pharmacokinetics of Antituberculosis Drugs in Breastfeeding Women · Phase 1 · not yet recruiting
- NCT07386171 — Micro-Ultrasound for Detecting Clinically Significant Prostate Cancer in Active Surveillance · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00689585 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McGill University Health Centre/Research Institute of the McGill University Health Centre
- Last refreshed: 11 May 2011
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00689585.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing