NCT00686231 is a Phase 1 clinical trial of Nitroglycerin 15mg in Healthy, sponsored by University of California, San Francisco.

Who is sponsoring NCT00686231?

NCT00686231 is sponsored by University of California, San Francisco.

What drugs are being tested in NCT00686231?

Interventions in NCT00686231: Nitroglycerin 15mg, Nitroglycerin 30mg, Lidocaine 20mg, Lidocaine 40mg, Placebo.

Is NCT00686231 still recruiting?

NCT00686231 is currently completed. Last updated 4 March 2020.

Are results published for NCT00686231?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2020-03-04 · How we verify

NCT00686231

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter

Completed Phase 1 Results posted Last updated 4 March 2020

What this trial tests

Phase 1 trial testing Nitroglycerin 15mg in Healthy in 19 participants. Completed in 1 December 2008.

Timeline

1 May 2008

Primary endpoint
1 December 2008

1 December 2008

Quick facts

Lead sponsor	University of California, San Francisco
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	19
Start date	1 May 2008
Primary completion	1 December 2008
Estimated completion	1 December 2008
Sites	1 location across United States

Drugs / interventions tested

Nitroglycerin 15mg — full drug profile →
Nitroglycerin 30mg — full drug profile →
Lidocaine 20mg — full drug profile →
Lidocaine 40mg — full drug profile →
Placebo

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

University of California, San Francisco

Who can join

Adults 18 to 35, any sex, with Healthy. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Percent Change in Diameter of Radial Artery as a Dose Test for Nitroglycerin
Time frame: Baseline, 10 minutes, 30 minutes, 60 minutes, and 120 minutes after topical application at Visit 1
Radial artery diameter was measured with ultrasonography using a high-frequency (13 MHz) linear array transducer 2 cm proximal to the radial styloid process.
Percent Change From Baseline in Radial Artery Diameter to Compare Combination of Nitroglycerin or Placebo and Lidocaine (20mg or 40mg)
Time frame: Baseline, 10 minutes, 30 minutes, 60 minutes, and 120 minutes after topical application at Visit 2
Radial artery diameter was measured with ultrasonography using a high-frequency (13 MHz) linear array transducer 2 cm proximal to the radial styloid process. To compare combination of (Lidocaine + Nitroglycerin) or (Lidocaine + placebo), at visit 2, participants randomized to Comparison A received 30mg NTG + 20mg Lidocaine on one wrist, and placebo + 20mg Lidocaine on the other wrist; participants

Sponsor's own description

The radial artery, which is located on the outer side of the forearm, can be used in interventional procedures, such as cardiac catheterization, to provide access to the arterial blood supply. In order to facilitate successful catheterization of the artery, a dilated artery and one free of arterial spasm is desirable. The proposed study will randomize twenty three healthy subjects in 2 visits to determine the effect of topical nitroglycerin on radial artery vasodilation. Radial artery diameter will be measured with ultrasound at regular intervals up to two hours.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Topical nitroglycerin and lidocaine locally vasodilate the radial artery without affecting systemic blood pressure: a dose-finding phase I study.
Majure DT, Hallaux M, Yeghiazarians Y, Boyle AJ. · · 2012 · cited 17× · PMID 22699036 · DOI 10.1016/j.jcrc.2012.04.019

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00686231 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, San Francisco
Last refreshed: 4 March 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00686231.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing