Who is sponsoring NCT00685880?

NCT00685880 is sponsored by Mayo Clinic.

What drugs are being tested in NCT00685880?

Interventions in NCT00685880: Prolotherapy (10% dextrose solution), Betamethasone.

What condition does NCT00685880 study?

NCT00685880 studies Thumb Carpometacarpal Joint Osteoarthritis.

Is NCT00685880 still recruiting?

NCT00685880 is currently terminated. Last updated 27 July 2012.

Are results published for NCT00685880?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2012-07-27 · How we verify

NCT00685880

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Randomized, Double Blind Comparison Trial of Prolotherapy (Dextrose) Compared to Corticosteroid Injection for the Treatment of Symptomatic Thumb Carpo-metacarpal Joint Arthritis

Terminated NA Results posted Last updated 27 July 2012

What this trial tests

NA trial testing Prolotherapy (10% dextrose solution) in Thumb Carpometacarpal Joint Osteoarthritis in 2 participants. Terminated before completion.

Timeline

1 May 2008

Primary endpoint
1 July 2010

1 July 2010

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	2
Start date	1 May 2008
Primary completion	1 July 2010
Estimated completion	1 July 2010
Sites	1 location across United States

Drugs / interventions tested

Prolotherapy (10% dextrose solution) — full drug profile →
Betamethasone (BETAMETHASONE) — full drug profile →

Conditions studied

Thumb Carpometacarpal Joint Osteoarthritis — all drugs for Thumb Carpometacarpal Joint Osteoarthritis →

Sponsor

Mayo Clinic

Who can join

45 and older, any sex, with Thumb Carpometacarpal Joint Osteoarthritis. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Number of Participants With a Decreased Pain Score >20%
Time frame: baseline, 6 month follow-up
Pain was measured on a 10 point visual analogue scale (VAS), with 0 meaning no pain, and 10 meaning extreme pain.

Sponsor's own description

Arthritis of the base of the thumb is a common debilitating problem. It is believed that laxity (loosening) of the joint leads to worsening arthritis in this joint. This can be treated by securing the joint surgically or symptoms can be treated with hand therapy and/or injection of corticosteroids. Recently prolotherapy (sugar water) has been shown to decrease looseness of joints and also be helpful for hand and knee arthritis. We hypothesize that prolotherapy injections for thumb arthritis will be equally or more beneficial to the patients than steroids.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

New Trends in Injection-Based Therapy for Thumb-Base Osteoarthritis: Where Are We and where Are We Going?
Tenti S, Cheleschi S, Mondanelli N, Giannotti S, et al · · 2021 · cited 12× · PMID 33927620 · DOI 10.3389/fphar.2021.637904
Pharmaceutical therapeutics for articular regeneration and restoration: state-of-the-art technology for screening small molecular drugs.
Chen Y, Sun H, Yao X, Yu Y, et al · · 2021 · cited 9× · PMID 34783870 · DOI 10.1007/s00018-021-03983-8

Verify or expand the search:

Other Mayo Clinic trials

Trials by the same sponsor.

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NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00685880 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 27 July 2012

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00685880.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing