NCT00681980 is a Phase 3 clinical trial of Valproic acid in Paraparesis Spastic Tropical, sponsored by University of Sao Paulo.

Who is sponsoring NCT00681980?

NCT00681980 is sponsored by University of Sao Paulo.

What drugs are being tested in NCT00681980?

Interventions in NCT00681980: Valproic acid, costicosteroids, valproid acid plus corticosteroids.

What condition does NCT00681980 study?

NCT00681980 studies Paraparesis Spastic Tropical.

Is NCT00681980 still recruiting?

NCT00681980 is currently completed. Last updated 1 December 2015.

Last reviewed 2015-12-01 · How we verify

NCT00681980

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Study Of Valproic Acid To Treat TSP/HAM Patients In Sao Paulo, Brazil

Completed Phase 3 Last updated 1 December 2015

What this trial tests

Phase 3 trial testing Valproic acid in Paraparesis Spastic Tropical in 60 participants. Completed in 1 December 2015.

Timeline

1 February 2008

Primary endpoint
1 September 2009

1 December 2015

Quick facts

Lead sponsor	University of Sao Paulo
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	60
Start date	1 February 2008
Primary completion	1 September 2009
Estimated completion	1 December 2015
Sites	1 location across Brazil

Drugs / interventions tested

Valproic acid (valproic acid) — full drug profile →
costicosteroids — full drug profile →
valproid acid plus corticosteroids — full drug profile →

Conditions studied

Paraparesis Spastic Tropical — all drugs for Paraparesis Spastic Tropical →

Sponsor

University of Sao Paulo

Who can join

Adults 18 to 70, any sex, with Paraparesis Spastic Tropical. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Neurological sacles
Time frame: 24 months

Sponsor's own description

Is the valproic acid efficacy to treat TSP/HAM

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Recent Updates on Viral Oncogenesis: Available Preventive and Therapeutic Entities.
Chowdhary S, Deka R, Panda K, Kumar R, et al · · 2023 · cited 13× · PMID 37486263 · DOI 10.1021/acs.molpharmaceut.2c01080

Verify or expand the search:

Other trials of Valproic acid

Trials testing the same drug.

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Other University of Sao Paulo trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00681980 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Sao Paulo
Last refreshed: 1 December 2015

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00681980.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing