NCT00679653 (HOS) is a Phase 3 clinical trial of sibutramine in Obesity, sponsored by Abbott.

Who is sponsoring NCT00679653?

NCT00679653 is sponsored by Abbott.

What drugs are being tested in NCT00679653?

Interventions in NCT00679653: sibutramine, sibutramine, verapamil/trandolapril, metoprolol/HCT, felodipine/ramipril.

What condition does NCT00679653 study?

NCT00679653 studies Obesity, Hypertension.

Is NCT00679653 still recruiting?

NCT00679653 is currently completed. Last updated 16 May 2008.

Last reviewed 2008-05-16 · How we verify

NCT00679653: HOS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives

Completed Phase 3 Last updated 16 May 2008

What this trial tests

Phase 3 trial testing sibutramine in Obesity in 171 participants. Completed.

Timeline

1 February 2002

Primary endpoint
1 December 2003

Quick facts

Lead sponsor	Abbott
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	171
Start date	1 February 2002
Primary completion	1 December 2003

Drugs / interventions tested

sibutramine (SIBUTRAMINE) — full drug profile →
sibutramine (SIBUTRAMINE) — full drug profile →
verapamil/trandolapril — full drug profile →
metoprolol/HCT — full drug profile →
felodipine/ramipril — full drug profile →

Conditions studied

Obesity — all drugs for Obesity →
Hypertension — all drugs for Hypertension →

Sponsor

Abbott — full company profile →

Who can join

Adults 20 to 65, any sex, with Obesity or Hypertension. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Systolic Blood Pressure
Time frame: Duration of Study
Diastolic Blood Pressure
Time frame: Duration of Study

Sponsor's own description

To study the effect of sibutramine treatment on weight reduction and blood pressure improvement in three groups with antihypertensive therapy whose blood pressure was not adequately controlled with antihypertensive combination treatment.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of sibutramine

Trials testing the same drug.

NCT01597609 — A Study to Characterise the Physiology of Weight Loss and Regain Under Dietary, Behavioural and Pharmacological Interven · Phase 1 · completed

Other recruiting trials for Obesity

Currently open trials in the same condition.

NCT07403604 — Effect of Insulin Lowering on Lipogenesis · Phase 1 · recruiting
NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT07272837 — Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass · recruiting
NCT07481630 — A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoart · Phase 3 · recruiting
NCT07527195 — Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscl · Phase 1 · recruiting

Other Abbott trials

Trials by the same sponsor.

NCT06217393 — Trial of Itopride 150mg Once a Day Versus Itopride 50 mg Thrice a Day; in Patients With Functional Dyspepsia · Phase 3 · completed
NCT05370703 — A Clinical Study to Evaluate the Effect of Mobile Applications "My A:Care" and "Smart Coach" on the Lipid-lowering Treat · completed
NCT05519514 — Bio-Equivalence Study of Budesonide Prolonged-release Tablets 9 Mg In Healthy Human Adult Subjects · Phase 1 · completed
NCT04784208 — A Study to Determine the Validity and Sensitivity of 'Questionnaire to Screen for HYpothyroidism' (Q'SHY) · unknown
NCT05175131 — Efficacy and Safety of Mebeverine + Simethicone in Patients With Functional Bowel Disorders · Phase 3 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00679653 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Abbott
Last refreshed: 16 May 2008

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00679653.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing