NCT00225498

Neurocognitive Effects of Ziprasidone: Relationship to Working Memory and Dopamine Blockade

Completed NA Results posted Last updated 2 September 2015

What this trial tests

NA trial testing ziprasidone vs risperidone or olanzapine in Schizophrenia in 35 participants. Completed in 1 October 2008.

Timeline

1 June 2002

Primary endpoint
1 October 2008

1 October 2008

Quick facts

Lead sponsor	Northwell Health
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	35
Start date	1 June 2002
Primary completion	1 October 2008
Estimated completion	1 October 2008
Sites	1 location across United States

Drugs / interventions tested

• ziprasidone vs risperidone or olanzapine — full drug profile →

Conditions studied

• Schizophrenia — all drugs for Schizophrenia →

Sponsor

Northwell Health — full company profile →

Who can join

Adults 18 to 50, any sex, with Schizophrenia. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Working Memory
  Time frame: 3 months
  California Verbal Learning Test (CVLT) trials 1 through 5 is a well established neuropsychological test of working memory. The maximum score is 80 which reflects a better outcome and the minimum score is 0 which reflects a worse outcome. The only meaningful analyses with adequate statistical power that could be reported were of the 10 schizophrenia patients who met nonresponse criteria to ziprasi

Sponsor's own description

Ziprasidone is a newer drug intended for the treatment of the symptoms of schizophrenia. This new drug may have an added benefit of being able to help with some of the difficulties in problem solving and memory that many patients with schizophrenia experience. The present study wants to look at ziprasidone and two other drugs frequently used to treat the symptoms of schizophrenia (risperidone and olanzapine) to see if problem solving and memory get better with ziprasidone treatment. Moreover, we will look at symptoms and how they change with treatment.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Ziprasidone for schizophrenia and bipolar disorder: a review of the clinical trials.
   Greenberg WM, Citrome L. · · 2007 · cited 51× · PMID 17627670 · DOI 10.1111/j.1527-3458.2007.00008.x
2. Ziprasidone versus other atypical antipsychotics for schizophrenia.
   Komossa K, Rummel-Kluge C, Hunger H, Schwarz S, et al · · 2009 · cited 33× · PMID 19821380 · DOI 10.1002/14651858.cd006627.pub2