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NCT00144261
An Open-label, Non-randomized, Single-arm Study to Investigate the Mechanism(s) by Which Nevirapine Increases Plasma HDL in HIV+ Subjects
Phase 4 trial testing nevirapine in HIV Infections in 15 participants. Completed.
1 December 2006
Quick facts
| Lead sponsor | Boehringer Ingelheim |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Primary purpose | prevention |
| Enrollment | 15 |
| Start date | 1 November 2003 |
| Primary completion | 1 December 2006 |
| Sites | 3 locations across United Kingdom, Netherlands |
Drugs / interventions tested
- nevirapine (NEVIRAPINE) — full drug profile →
Conditions studied
- HIV Infections — all drugs for HIV Infections →
- Metabolism, Lipids — all drugs for Metabolism, Lipids →
Sponsor
Boehringer Ingelheim — full company profile →
Who can join
18 and older, any sex, with HIV Infections or Metabolism, Lipids. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
1. In order to obtain further insight as to how NVP affects HDL metabolism, the in vivo kinetics of the HDL apolipoprotein, Apo A-1, before and 6 weeks after initiation of NVP containing treatment were evaluated. In addition, the activity of the key enzymes related to HDL metabolism were assessed. \[ Designated as safety issue: No \] 2. In order to determine the relevance of the HDL increase in decreasing cardiovascular risk in HIV-positive subjects we evaluated endothelial function (FMD) as a surrogate marker for cardiovascular disease in patients. \[ Designated as safety issue: No \]
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT00144261
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00144261 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Boehringer Ingelheim
- Last refreshed: 31 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00144261.
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