Last reviewed · How we verify
NCT00002561
Radiation Therapy and Chemotherapy in Treating Patients With Hodgkin's Disease
Phase 3 trial testing bleomycin sulfate in Hodgkin Lymphoma in 405 participants. Completed in 6 January 2012.
15 August 2011
Quick facts
| Lead sponsor | NCIC Clinical Trials Group |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 405 |
| Start date | 25 January 1994 |
| Primary completion | 15 August 2011 |
| Estimated completion | 6 January 2012 |
| Sites | 22 locations across Italy, Canada, United Kingdom |
Drugs / interventions tested
- bleomycin sulfate — full drug profile →
- dacarbazine (dacarbazine) — full drug profile →
- doxorubicin hydrochloride — full drug profile →
- vinblastine
- radiation therapy
Conditions studied
- Hodgkin Lymphoma — all drugs for Hodgkin Lymphoma →
Sponsor
NCIC Clinical Trials Group
Who can join
16 and older, any sex, with Hodgkin Lymphoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells. Combining more than one drug or combining chemotherapy with radiation therapy may kill more tumor cells. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy, with or without chemotherapy, with chemotherapy alone in treating patients with stage I or stage IIA Hodgkin's disease.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
ABVD alone versus radiation-based therapy in limited-stage Hodgkin's lymphoma.
Meyer RM, Gospodarowicz MK, Connors JM, Pearcey RG, et al · · 2012 · cited 246× · PMID 22149921 · DOI 10.1056/nejmoa1111961 -
An individual patient-data comparison of combined modality therapy and ABVD alone for patients with limited-stage Hodgkin lymphoma.
Hay AE, Klimm B, Chen BE, Goergen H, et al · · 2013 · cited 31× · PMID 24121121 · DOI 10.1093/annonc/mdt389 -
Patient-reported outcomes in Hodgkin lymphoma trials: a systematic review.
Oliva EN, Ionova T, Laane E, Csenar M, et al · · 2024 · cited 4× · PMID 38544841 · DOI 10.3389/fonc.2024.1353101
Verify or expand the search:
- PubMed search for NCT00002561
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of bleomycin sulfate
Trials testing the same drug.
- NCT01026220 — Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin Lymphoma · Phase 3 · completed
- NCT00678327 — Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Sta · Phase 3 · completed
- NCT00104676 — Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors · Phase 3 · completed
- NCT00053352 — Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors · Phase 3 · completed
- NCT00002565 — Combination Chemotherapy in Treating Patients With Intermediate-Grade or Immunoblastic Non-Hodgkin's Lymphoma · Phase 3 · completed
Other recruiting trials for Hodgkin Lymphoma
Currently open trials in the same condition.
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- NCT07566377 — Cord Blood Transplantation in Children and Young Adults With Blood Cancer · Phase 2 · recruiting
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- NCT06176690 — Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas · Phase 1 · recruiting
- NCT07002216 — BrECADD Therapy in Stage 2 B-IV Hodgkin Lymphoma · Phase 2 · recruiting
Other NCIC Clinical Trials Group trials
Trials by the same sponsor.
- NCT01916187 — Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma · Phase 1 · withdrawn
- NCT01830621 — BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma · Phase 3 · completed
- NCT01652144 — A Phase II Study of AT7519M, a CDK Inhibitor, in Patients With Relapsed Mantle Cell Lymphoma · Phase 2 · completed
- NCT01627054 — A Phase II Study of AT7519M, a CDK Inhibitor, in Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia · Phase 2 · completed
- NCT01486368 — A Phase II Study of PF-03446962 in Patients With Advanced Malignant Pleural Mesothelioma · Phase 2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00002561 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by NCIC Clinical Trials Group
- Last refreshed: 14 April 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00002561.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing