Last reviewed · How we verify
NCT00001921
Electrophysiology and Blood Flow in Patients With Schizophrenia and Their Siblings
trial in Healthy in 1,386 participants. Completed in 8 June 2018.
Quick facts
| Lead sponsor | National Institute of Mental Health (NIMH) |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,386 |
| Start date | 21 September 1999 |
| Estimated completion | 8 June 2018 |
| Sites | 1 location across United States |
Conditions studied
- Healthy — all drugs for Healthy →
- Schizophrenia — all drugs for Schizophrenia →
Sponsor
National Institute of Mental Health (NIMH)
Who can join
Adults 18 to 55, any sex, with Healthy or Schizophrenia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will explore how the brain works during memory testing in an effort to understand why some patients with schizophrenia have memory difficulties. Patients with schizophrenia and their unaffected family members are eligible for this study. Studying family members may help identify the genes related to the memory deficit in schizophrenia. Normal volunteers will also be studied. Normal volunteers, patients with schizophrenia, and their family members interested in participating in this study will be screened with a complete medical examination and psychiatric assessment, and performance of simple tasks. Study participants will be shown numbers on a screen and asked to recall them after a brief period. This will be done during electroencephalographic (EEG) recording, in which electrodes attached to the scalp measure the brain s electrical activity. The same test will be repeated while the patient has magnetic resonance imaging of the brain. The combined MRI and EEG testing will permit better localization of the brain s electrical activity. ...
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Spatiotemporal Alterations in Working Memory-Related Beta Band Neuromagnetic Activity of Patients With Schizophrenia On and Off Antipsychotic Medication: Investigation With MEG.
Rubinstein DY, Eisenberg DP, Carver FW, Holroyd T, et al · · 2023 · cited 4× · PMID 36772948 · DOI 10.1093/schbul/sbac178
Verify or expand the search:
- PubMed search for NCT00001921
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00001921 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institute of Mental Health (NIMH)
- Last refreshed: 17 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00001921.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing