Sigma-1 receptor — Drug Target

All drugs that target Sigma-1 receptor — marketed and clinical-stage. Includes 4 drug classes acting on this target.

Drug classes

Sigma-1 receptor agonist combination · sigma-1 receptor modulator · Sigma-1 receptor agonist · sigma-1 receptor agonist

Marketed (1)

• Nuedexta (20/10) · St. Joseph's Hospital and Medical Center, Phoenix · Sigma-1 receptor agonist combination · Neurology
  Nuedexta combines dextromethorphan (a sigma-1 receptor agonist) and quinidine (a CYP2D6 inhibitor) to reduce involuntary emotional expression disorder (pseudobulbar affect) by modulating emotional pathways in the brain.

Phase 3 pipeline (4)

• GP40081 · Geropharm · sigma-1 receptor modulator · Neurology
  GP40081 is a small molecule drug that targets the sigma-1 receptor.
• AVP-786-18 · Otsuka Pharmaceutical Development & Commercialization, Inc. · Sigma-1 receptor agonist · Neurology
  AVP-786 is a combination of deuterated dextromethorphan and quinidine that enhances sigma-1 receptor signaling to reduce neurological symptoms.
• AVP-786-42.63 · Otsuka Pharmaceutical Development & Commercialization, Inc. · Sigma-1 receptor agonist · Neurology
  AVP-786 is a combination of deuterated dextromethorphan and quinidine that enhances sigma-1 receptor signaling to reduce neuroinflammation and neurodegeneration.
• AVP-786-28 · Otsuka Pharmaceutical Development & Commercialization, Inc. · Sigma-1 receptor agonist · Neurology
  AVP-786 is a combination of deuterated dextromethorphan and quinidine that enhances sigma-1 receptor signaling to reduce agitation and behavioral symptoms in neurodegenerative diseases.

Phase 2 pipeline (2)

• ANAVEX2-73 oral liquid · Anavex Life Sciences Corp. · sigma-1 receptor agonist · Neurology
  ANAVEX2-73 is an oral liquid formulation of a sigma-1 receptor agonist.
• EN3270 · Durect · sigma-1 receptor agonist · Pain
  EN3270 is a small molecule that targets the sigma-1 receptor.