What are Sigma-1 receptor agonist drugs?

Sigma-1 receptor agonist drugs are pharmacologic agents that share a common mechanism (typically targeting Sigma-1 receptor). 0 are currently marketed, with 7 more in clinical development.

Sigma-1 receptor agonist

0 marketed 4 in Phase 3 3 in Phase 2

This page covers all Sigma-1 receptor agonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Sigma-1 receptor, Sigma-1 receptor (S1R), sigma-1 receptor.

Targets

Sigma-1 receptor · Sigma-1 receptor (S1R) · sigma-1 receptor · Sigma-1 receptor (σ1R)

Phase 3 pipeline (4)

AVP-786-42.63 · Otsuka Pharmaceutical Development & Commercialization, Inc. · Neurology
AVP-786 is a combination of deuterated dextromethorphan and quinidine that enhances sigma-1 receptor signaling to reduce neuroinflammation and neurodegeneration.
AVP-786-28 · Otsuka Pharmaceutical Development & Commercialization, Inc. · Neurology
AVP-786 is a combination of deuterated dextromethorphan and quinidine that enhances sigma-1 receptor signaling to reduce agitation and behavioral symptoms in neurodegenerative diseases.
ANAVEX2-73 · Anavex Life Sciences Corp. · Neurology
ANAVEX2-73 is a sigma-1 receptor agonist that activates neuroprotective pathways to treat neurodegenerative diseases.
AVP-786-18 · Otsuka Pharmaceutical Development & Commercialization, Inc. · Neurology
AVP-786 is a combination of deuterated dextromethorphan and quinidine that enhances sigma-1 receptor signaling to reduce neurological symptoms.

Phase 2 pipeline (3)

ANAVEX2-73 oral liquid · Anavex Life Sciences Corp. · Neurology
ANAVEX2-73 is an oral liquid formulation of a sigma-1 receptor agonist.
EN3270 · Durect · Pain
EN3270 is a small molecule that targets the sigma-1 receptor.
ANAVEX3-71 oral capsules · Anavex Life Sciences Corp. · Neurology
ANAVEX3-71 is a sigma-1 receptor agonist that modulates neuroprotective and neuroinflammatory pathways in the central nervous system.