guanylate cyclase — Drug Target

All drugs that target guanylate cyclase — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Nitrate Vasodilator [EPC] · Nitrate · vasodilator

Marketed (1)

• Nitroglycerin · Fougera · Nitrate Vasodilator [EPC] · Metabolic
  Nitroglycerin forms nitric oxide, activating guanylate cyclase and increasing cyclic GMP, leading to smooth muscle relaxation and vasodilation.

Phase 3 pipeline (2)

• Transdermal glyceryl trinitrate patch · University of Nottingham · Nitrate · Cardiovascular
  Transdermal glyceryl trinitrate patch works by releasing nitric oxide, which causes vasodilation and reduces blood pressure.
• glyceryl nitrate · Hvidovre University Hospital · vasodilator · Cardiovascular
  Glyceryl nitrate acts as a vasodilator by releasing nitric oxide, which relaxes vascular smooth muscle and reduces blood pressure.