Last reviewed 2026-04-23 · How we verify

glyceryl nitrate

Glyceryl nitrate acts as a vasodilator by releasing nitric oxide, which relaxes vascular smooth muscle and reduces blood pressure.

Glyceryl nitrate acts as a vasodilator by releasing nitric oxide, which relaxes vascular smooth muscle and reduces blood pressure. Used for Angina pectoris, Atrial fibrillation for rate control.

At a glance

Mechanism of action

This results in decreased peripheral resistance and a subsequent decrease in blood pressure. Nitric oxide also inhibits platelet aggregation and adhesion, further contributing to its vasodilatory effects.

Approved indications

• Angina pectoris
• Atrial fibrillation for rate control

Common side effects

• Headache
• Dizziness
• Hypotension

Key clinical trials

• Nitrate Use to Obtain Radial Spasm Embarrassment (NURSE - TTS Trial) (PHASE3)
• The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia (NA)
• Effects of Nicorandil on Angina Symptoms in Patients With Coronary Slow Flow (PHASE4)
• Does Glyceryl Nitrate Prevent Post-Endoscopic Retrograde Cholangiopancreaticography (ERCP) Pancreatitis? (PHASE3)
• Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina (PHASE4)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• glyceryl nitrate CI brief — competitive landscape report
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• Hvidovre University Hospital portfolio CI