Estrogen receptor alpha and beta — Drug Target

All drugs that target Estrogen receptor alpha and beta — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Estrogen replacement therapy (topical) · Selective estrogen receptor modulator (SERM) combined with estrogen replacement · Selective estrogen receptor modulator (SERM) combination

Marketed (2)

• Estrogen vaginal cream · The University of Texas Health Science Center, Houston · Estrogen replacement therapy (topical) · Women's Health / Gynecology
  Estrogen vaginal cream delivers estrogen directly to vaginal tissues to restore estrogen levels and relieve symptoms of vaginal atrophy and genitourinary syndrome of menopause.
• Clomiphene citrate and Estradiol · Maher elesawi kamel elesawi · Selective estrogen receptor modulator (SERM) combined with estrogen replacement · Endocrinology / Reproductive Medicine
  Clomiphene citrate acts as a selective estrogen receptor modulator to block negative feedback and increase gonadotropin secretion, while estradiol provides exogenous estrogen supplementation.

Phase 3 pipeline (1)

• DHEA and Acolbifene · EndoCeutics Inc. · Selective estrogen receptor modulator (SERM) combination · Women's Health / Endocrinology
  DHEA and acolbifene work together as a selective estrogen receptor modulator (SERM) combination to provide estrogen-like benefits in bone and vaginal tissue while minimizing systemic estrogen exposure.