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Clomiphene citrate and Estradiol
Clomiphene citrate acts as a selective estrogen receptor modulator to block negative feedback and increase gonadotropin secretion, while estradiol provides exogenous estrogen supplementation.
Clomiphene citrate acts as a selective estrogen receptor modulator to block negative feedback and increase gonadotropin secretion, while estradiol provides exogenous estrogen supplementation. Used for Female infertility due to anovulation, Hormone replacement therapy, Ovulation induction.
At a glance
| Generic name | Clomiphene citrate and Estradiol |
|---|---|
| Also known as | Clomid and Estradiol valerate |
| Sponsor | Maher elesawi kamel elesawi |
| Drug class | Selective estrogen receptor modulator (SERM) combined with estrogen replacement |
| Target | Estrogen receptor alpha and beta |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Reproductive Medicine |
| Phase | FDA-approved |
Mechanism of action
Clomiphene citrate competitively binds estrogen receptors in the hypothalamus and pituitary, blocking endogenous estrogen feedback and thereby increasing FSH and LH secretion to stimulate ovulation or spermatogenesis. The addition of estradiol provides direct estrogen replacement or supplementation. This combination is used in hormone replacement and fertility protocols.
Approved indications
- Female infertility due to anovulation
- Hormone replacement therapy
- Ovulation induction
Common side effects
- Hot flashes
- Ovarian hyperstimulation syndrome (OHSS)
- Headache
- Nausea
- Visual disturbances
- Abdominal discomfort
Key clinical trials
- The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface.
- Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction (NA)
- Effectiveness of Low Dose Gonadotropin Stimulation Protocol Vs High Dose Gonadotropin Protocol in Poor Responders (EARLY_PHASE1)
- HRT Versus MOS for Endometrial Preparation Prior to FET in Non PCOS Patients (PHASE4)
- The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol (NA)
- Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility (PHASE4)
- The Four Methods of Ovarian Stimulation in Patients With Polycystic Ovarian Syndrome (NA)
- the Effect of Clomiphene Citrate Plus Estradiol Valerate Versus Letrozole on Endometrial Thickness and Pregnancy Rate in Infertile Women (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Clomiphene citrate and Estradiol CI brief — competitive landscape report
- Clomiphene citrate and Estradiol updates RSS · CI watch RSS
- Maher elesawi kamel elesawi portfolio CI