dihydroorotate dehydrogenase — Drug Target

All drugs that target dihydroorotate dehydrogenase — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Pyrimidine Synthesis Inhibitor [EPC] · 8-aminoquinoline · Pyrimidine synthesis inhibitor

Marketed (1)

• Aubagio · Sanofi · Pyrimidine Synthesis Inhibitor [EPC] · Immunology
  Teriflunomide inhibits dihydroorotate dehydrogenase, reducing activated lymphocytes in the CNS.

Phase 3 pipeline (1)

• Tafenoquine Oral Tablet · State University of New York - Upstate Medical University · 8-aminoquinoline · Infectious Diseases
  Tafenoquine is an antimalarial drug that works by targeting the Plasmodium parasite's heme detoxification pathway.

Phase 2 pipeline (1)

• Gimeracil and Oteracil Porassium Capsules · Beijing Biohealthcare Biotechnology Co.,Ltd · Pyrimidine synthesis inhibitor · Oncology
  Inhibits dihydroorotate dehydrogenase