ClC-2 chloride channel — Drug Target

All drugs that target ClC-2 chloride channel — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

ClC-2 chloride channel activator · Chloride channel activator

Marketed (2)

• lubiprostone (Amitiza) · Henry Ford Health System · ClC-2 chloride channel activator · Gastroenterology
  Lubiprostone activates ClC-2 chloride channels in the intestinal epithelium to increase intestinal fluid secretion and promote bowel movements.
• Amitiza (Lubiprostone) · Brooke Army Medical Center · Chloride channel activator · Gastroenterology
  Lubiprostone activates ClC-2 chloride channels in the intestinal epithelium to increase fluid secretion into the bowel lumen, promoting stool passage.

Phase 3 pipeline (2)

• Cohort 1: Lubiprostone Capsule, Fasted · Sucampo Pharma Americas, LLC · Chloride channel activator · Gastroenterology
  Lubiprostone activates ClC-2 chloride channels in the intestinal epithelium to increase intestinal fluid secretion and promote bowel motility.
• Lubiprostone 24 · Sucampo Pharma Americas, LLC · ClC-2 chloride channel activator · Gastroenterology
  Lubiprostone is a ClC-2 chloride channel activator that increases intestinal fluid secretion and promotes bowel motility to relieve constipation.