Alpha-2-delta-1 subunit of voltage-gated calcium channels — Drug Target
All drugs that target Alpha-2-delta-1 subunit of voltage-gated calcium channels — marketed and clinical-stage. Includes 5 drug classes acting on this target.
Drug classes
Anticonvulsant; Gabapentinoid · Anticonvulsant; gabapentinoid · Gabapentinoid; anticonvulsant; anxiolytic · Gabapentinoid; anticonvulsant; anxiolytic analgesic · Gabapentinoid
Marketed (3)
- Gabapentin Capsules · EpiCept Corporation · Anticonvulsant; Gabapentinoid · Neurology
Gabapentin reduces neuronal excitability by binding to the alpha-2-delta subunit of voltage-gated calcium channels, thereby decreasing the release of excitatory neurotransmitters. - Standard dose gabapentin · Mario Negri Institute for Pharmacological Research · Anticonvulsant; gabapentinoid · Neurology
Gabapentin reduces neuronal excitability by binding to the alpha-2-delta subunit of voltage-gated calcium channels, thereby decreasing calcium influx and neurotransmitter release. - pregabalin capsules · AstraZeneca · Gabapentinoid; anticonvulsant; anxiolytic · Neurology; Pain Management; Psychiatry
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters.
Phase 3 pipeline (3)
- Perioperative Pregabalin · McMaster University · Gabapentinoid; anticonvulsant; anxiolytic analgesic · Pain Management; Perioperative Medicine
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters and thereby decreasing neuropathic pain and anxiety. - Pregabalin add-on therapy · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · Gabapentinoid · Neurology
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters. - Placebo matched with pregabalin · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · Gabapentinoid · Neurology
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters.