Adenosine A2A receptor — Drug Target

All drugs that target Adenosine A2A receptor — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

Adenosine A2A receptor agonist · Adenosine A2A receptor antagonist · adenosine A2A receptor antagonist

Marketed (3)

• Regadenoson myocardial perfusion imaging · University of Colorado, Denver · Adenosine A2A receptor agonist · Cardiovascular
  Regadenoson is a selective adenosine A2A receptor agonist that increases coronary blood flow to detect areas of reduced perfusion during cardiac imaging.
• Regadenoson MRI myocardial blood flow · University of Colorado, Denver · Adenosine A2A receptor agonist · Cardiovascular
  Regadenoson is a selective adenosine A2A receptor agonist that increases coronary blood flow to enable assessment of myocardial perfusion during cardiac MRI imaging.
• Regadenoson (Lexiscan) · Brigham and Women's Hospital · Adenosine A2A receptor agonist · Cardiovascular
  Regadenoson is a selective adenosine A2A receptor agonist that increases coronary blood flow to induce cardiac stress for diagnostic imaging.

Phase 3 pipeline (4)

• Istradefylline (KW-6002) · Kyowa Kirin, Inc. · Adenosine A2A receptor antagonist · Neurology
  Istradefylline is an adenosine A2A receptor antagonist that blocks inhibitory signaling in the basal ganglia, thereby enhancing dopaminergic motor control.
• Regadenoson peripheral - central · Lokien van Nunen · Adenosine A2A receptor agonist · Cardiovascular
  Regadenoson is an adenosine A2A receptor agonist that causes coronary vasodilation to increase blood flow, used for cardiac stress testing.
• AD109 · Apnimed · Adenosine A2A receptor antagonist · Oncology
  AD109 is an adenosine A2A receptor antagonist that blocks inhibitory signaling in the tumor microenvironment to enhance immune cell activation.
• Regadenoson peripheral - peripheral · Lokien van Nunen · Adenosine A2A receptor agonist · Cardiovascular
  Regadenoson is an adenosine A2A receptor agonist that causes peripheral vasodilation to increase blood flow, used as a pharmacologic stress agent for cardiac imaging.

Phase 2 pipeline (1)

• AZD4635 · AstraZeneca · adenosine A2A receptor antagonist · Oncology
  AZD4635 is a small molecule inhibitor of the adenosine A2A receptor.