US Patent

US12195496 — 2′-deoxy-2′,2′-difluorotetrahydrouridines with high purity and methods of making the same

Formulation · Assigned to Otsuka Pharmaceutical Co Ltd · Expires 2040-10-07 · 14y remaining

Vulnerability score 55/100 Moderate — design-around opportunities exist

What this patent protects

This patent protects methods for synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution.

USPTO Abstract

The invention relates to methods of synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.

Drugs covered by this patent

Patent Metadata

Patent number
US12195496
Jurisdiction
US
Classification
Formulation
Expires
2040-10-07
Drug substance claim
No
Drug product claim
Yes
Assignee
Otsuka Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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