CN102008488B — 一种曲安奈德眼用制剂及其制备方法
Assigned to HUIZHOU CITY BAIJIRUI MEDICAL CO Ltd · Expires 2012-10-10 · 14y expired
What this patent protects
本发明涉及一种曲安奈德眼用制剂及其制备方法，该眼用制剂主要组分为曲安奈德0.05~0.5%，氯化钠0.1~0.9%，羟丙基甲基纤维素1.0~5.0%，聚山梨酯800.05~0.2%，缓冲溶液适量和无菌纯水，取已灭菌的曲安奈德和聚山梨酯80混匀，加适量无菌纯水，制成混悬液，将氯化钠、乙二胺四乙酸钙钠、苯扎溴铵、乙酸、乙酸钠、硼酸，加无菌纯水适量溶解得溶液，然后将所得的混悬液和溶液混匀，100℃灭菌，灭菌后的溶液和羟丙基甲基纤维素溶液混匀，加无菌纯水至液体体积的90%；最后用无菌NaOH或HCl溶液调节pH值为5~7，用无菌纯水稀释定容即得眼用制剂，该滴眼剂…
USPTO Abstract
本发明涉及一种曲安奈德眼用制剂及其制备方法，该眼用制剂主要组分为曲安奈德0.05~0.5%，氯化钠0.1~0.9%，羟丙基甲基纤维素1.0~5.0%，聚山梨酯800.05~0.2%，缓冲溶液适量和无菌纯水，取已灭菌的曲安奈德和聚山梨酯80混匀，加适量无菌纯水，制成混悬液，将氯化钠、乙二胺四乙酸钙钠、苯扎溴铵、乙酸、乙酸钠、硼酸，加无菌纯水适量溶解得溶液，然后将所得的混悬液和溶液混匀，100℃灭菌，灭菌后的溶液和羟丙基甲基纤维素溶液混匀，加无菌纯水至液体体积的90%；最后用无菌NaOH或HCl溶液调节pH值为5~7，用无菌纯水稀释定容即得眼用制剂，该滴眼剂具有合适的黏度，生物利用度高，对眼部刺激性少等优点。
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Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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