CA2702274A1 — 2'-flu0r0-2'-deoxytetrahydrouridines as cytidine deaminase inhibitors
Assigned to Otsuka Pharmaceutical Co Ltd · Expires 2009-04-23 · 17y expired
What this patent protects
The present invention provides tetrahydrouridine derivative compounds of Formula I, or a pharmaceutically acceptable salt thereof: (see formula I) wherein the carbon marked by an asterisk may have an (R) or an (S) configuration; and wherein R1 and R2 are fluoro. The compounds of …
USPTO Abstract
The present invention provides tetrahydrouridine derivative compounds of Formula I, or a pharmaceutically acceptable salt thereof: (see formula I) wherein the carbon marked by an asterisk may have an (R) or an (S) configuration; and wherein R1 and R2 are fluoro. The compounds of Formula I are inhibitors of the enzyme cytidine deaminase. The invention also provides the pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds in the treatment of cancer.
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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