Mechanism of action
The specific biochemical interaction by which a drug produces its pharmacologic effect.
Definition
A drug's mechanism of action is the specific molecular interaction (receptor binding, enzyme inhibition, transporter blockade, etc.) by which it produces its therapeutic effect. Examples: PD-1 inhibitors block the PD-1 receptor on T cells; GLP-1 agonists activate the GLP-1 receptor on pancreatic beta cells; ACE inhibitors block angiotensin-converting enzyme.
See also
- Pharmacokinetics — How the body processes a drug — absorption, distribution, metabolism, excretion (ADME).
- Pharmacodynamics — How a drug affects the body — its biological effects, receptor occupancy, and dose-response.