Generic entry timeline

Cialis generics — when can they launch?

Cialis (tadalafil) · Eli Lilly · 4 active US patents · 0 expired

Earliest patent expiry
2038-12-24
13 years remaining
Full patent estate to
2038-12-24
complete protection through 2038
FDA approval
Eli Lilly

Where Cialis sits in the generic timeline

Long-dated protection: earliest active US patent for Cialis extends to 2038 (~13 years out). Generic competition is at least 4 years away. Lifecycle moves (new formulations, label extensions, combination filings) typically execute 18-36 months ahead of cliff.

Under US Hatch-Waxman, a generic enters via an ANDA (Abbreviated New Drug Application) and may file with one of four Paragraph IV certifications attacking the brand's listed patents. If the brand sues within 45 days, a 30-month FDA approval stay is triggered. First Para IV filer typically gets 180-day market exclusivity.

Patent estate by type — active patents

Method-of-use patents only carve out specific indications; generics can launch with a "skinny label" omitting those uses. Composition-of-matter patents block the molecule itself.

  • Method of Use — 4 patents

FDA U-codes carved out by Cialis patents

Method-of-use patents are listed against specific FDA Patent Use Codes ("U-codes") representing carved-out indications. Generics can launch with a label that omits these uses.

U-codeDescription
U-3397(no description)

Sample patent estate

Showing 4 of 4 active US patents. View full estate on the Cialis drug page →

  • US12186322 Method of Use · expires 2038-12-24
    This patent protects liquid oral formulations of the PDE V inhibitor tadalafil, used to treat conditions such as pulmonary arterial hypertension and erectile dysfunction.
    USPTO title: Liquid oral formulations for tadalafil
  • US11666576 Method of Use · expires 2038-12-24
    This patent protects liquid oral formulations of the PDE V inhibitor tadalafil, used to treat conditions such as pulmonary arterial hypertension and erectile dysfunction.
    USPTO title: Liquid oral formulations for tadalafil
  • US11382917 Method of Use · expires 2038-12-24
    This patent protects liquid oral formulations of the PDE V inhibitor tadalafil, used to treat conditions such as pulmonary arterial hypertension and erectile dysfunction.
    USPTO title: Liquid oral formulations for tadalafil
  • US11975006 Method of Use · expires 2038-12-24
    This patent protects liquid oral formulations of the PDE V inhibitor tadalafil, used to treat conditions such as pulmonary arterial hypertension and erectile dysfunction.
    USPTO title: Liquid oral formulations for tadalafil

Sources

Patent term extensions (PTR, pediatric exclusivity), Hatch-Waxman 30-month stays, and FDA regulatory exclusivity (NCE/ODE/PED) may shift the effective generic entry date. Not legal advice.

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