Generic entry timeline

BENDAMUSTINE HYDROCHLORIDE generics — when can they launch?

BENDAMUSTINE HYDROCHLORIDE (BENDAMUSTINE HYDROCHLORIDE) · · 69 active US patents · 10 expired

Earliest patent expiry
2026-07-12
expired
Full patent estate to
2042-07-29
complete protection through 2042
FDA approval
2008

Where BENDAMUSTINE HYDROCHLORIDE sits in the generic timeline

All listed Orange Book patents for BENDAMUSTINE HYDROCHLORIDE have expired. Generic entry is permitted, and ANDA filers can launch without patent infringement risk. Hatch-Waxman exclusivity (NCE/ODE/PED) may still apply if recently approved.

Under US Hatch-Waxman, a generic enters via an ANDA (Abbreviated New Drug Application) and may file with one of four Paragraph IV certifications attacking the brand's listed patents. If the brand sues within 45 days, a 30-month FDA approval stay is triggered. First Para IV filer typically gets 180-day market exclusivity.

Patent estate by type — active patents

Method-of-use patents only carve out specific indications; generics can launch with a "skinny label" omitting those uses. Composition-of-matter patents block the molecule itself.

  • Method of Use — 31 patents
  • Other — 22 patents
  • Formulation — 14 patents
  • Composition of Matter — 2 patents

FDA U-codes carved out by BENDAMUSTINE HYDROCHLORIDE patents

Method-of-use patents are listed against specific FDA Patent Use Codes ("U-codes") representing carved-out indications. Generics can launch with a label that omits these uses.

U-codeDescription
U-1402(no description)
U-1952(no description)
U-1972(no description)
U-1542(no description)
U-1971(no description)

Sample patent estate

Showing 6 of 69 active US patents. View full estate on the BENDAMUSTINE HYDROCHLORIDE drug page →

  • US8609863 Other · expires 2026-07-12
    This patent protects pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use.
    USPTO title: Bendamustine pharmaceutical compositions
  • US8791270 Other · expires 2026-07-12
    This patent protects pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use.
    USPTO title: Bendamustine pharmaceutical compositions
  • US8791270 Other · expires 2026-07-12
    This patent protects pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use.
    USPTO title: Bendamustine pharmaceutical compositions
  • US8791270 Other · expires 2026-07-12
    This patent protects pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use.
    USPTO title: Bendamustine pharmaceutical compositions
  • US8895756 Other · expires 2026-07-12
    This patent protects pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use.
    USPTO title: Bendamustine pharmaceutical compositions
  • US8895756 Other · expires 2026-07-12
    This patent protects pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use.
    USPTO title: Bendamustine pharmaceutical compositions

Sources

Patent term extensions (PTR, pediatric exclusivity), Hatch-Waxman 30-month stays, and FDA regulatory exclusivity (NCE/ODE/PED) may shift the effective generic entry date. Not legal advice.

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