Last reviewed · How we verify
BENDAMUSTINE HYDROCHLORIDE
At a glance
| Generic name | BENDAMUSTINE HYDROCHLORIDE |
|---|---|
| Modality | Small molecule |
| Phase | FDA-approved |
| First approval | 2008 |
Approved indications
Common side effects
- Pyrexia
- Nausea
- Vomiting
- Fatigue
- Diarrhea
- Asthenia
- Rash
- Weight decreased
- Hyperuricemia
- Nasopharyngitis
- Pruritus
- Hypersensitivity
Serious adverse events
- Hypertensive crisis
- Worsening hypertension
- Pyrexia (Grade 3/4)
- Rash (Grade 3/4)
- Hyperuricemia (Grade 3/4)
- Infection (Grade 3/4)
- Hypersensitivity (Grade 3/4)
- Fatigue (Grade 3/4)
- Diarrhea (Grade 3/4)
- Cough (Grade 3/4)
Key clinical trials
- A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003) (PHASE2, PHASE3)
- Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (PHASE3)
- Obinutuzumab With or Without Umbralisib, Lenalidomide, or Combination Chemotherapy in Treating Patients With Relapsed or Refractory Grade I-IIIa Follicular Lymphoma (PHASE2)
- A Study of DZD8586 Versus Investigator's Choice in r/r CLL/SLL (TAI-SHAN6) (PHASE3)
- CD20 Monoclonal Antibody-Based First-Line Therapy in Treatment-Naive Marginal Zone B-Cell Lymphoma
- A Phase III Trial Comparing Tisagenlecleucel to Standard of Care (SoC) in Adult Participants With r/r Follicular Lymphoma (PHASE3)
- A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma (PHASE2)
- Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- BENDAMUSTINE HYDROCHLORIDE CI brief — competitive landscape report
- BENDAMUSTINE HYDROCHLORIDE updates RSS · CI watch RSS