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Zinc-Oxide Eugenol Sealer
Zinc-oxide eugenol sealer hardens and sets through a chelation reaction between zinc oxide and eugenol, forming a rigid matrix that seals the root canal system.
Zinc-oxide eugenol sealer hardens and sets through a chelation reaction between zinc oxide and eugenol, forming a rigid matrix that seals the root canal system. Used for Root canal obturation and sealing in endodontic therapy.
At a glance
| Generic name | Zinc-Oxide Eugenol Sealer |
|---|---|
| Sponsor | Institucion Universitaria Colegios de Colombia |
| Drug class | Root canal sealer |
| Modality | Small molecule |
| Therapeutic area | Dentistry |
| Phase | FDA-approved |
Mechanism of action
Zinc oxide reacts with eugenol to form zinc eugenolate, a hard, insoluble compound that provides mechanical sealing of the root canal. The material exhibits antimicrobial properties due to eugenol's phenolic nature and zinc's antimicrobial activity. This combination creates a biocompatible barrier that prevents bacterial recontamination and leakage of periapical fluids.
Approved indications
- Root canal obturation and sealing in endodontic therapy
Common side effects
- Allergic reaction to eugenol
- Tissue irritation if extruded beyond apex
- Discoloration of tooth structure
Key clinical trials
- THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE (NA)
- Endodontic Post-operative Pain Evaluation of Patients After Using Endomethasone N or Endomethasone SP (EndoPOP) (NA)
- Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars. (NA)
- Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement (PHASE4)
- Evaluation of Postoperative Pain With Resin Based Sealer vs Zinc Oxide Eugenol Based Sealer After Single Visit Endodontic (NA)
- Postoperative Pain After Root Canal Obturation With Sealer Containing Prednisolone. (NA)
- Outcome of Endodontic Treatment in Patient Treated With a Hydraulic Sealer (PHASE4)
- Pain After Root Canal Obturation With Sealer Containing or Not 1% Enoxolone (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Zinc-Oxide Eugenol Sealer CI brief — competitive landscape report
- Zinc-Oxide Eugenol Sealer updates RSS · CI watch RSS
- Institucion Universitaria Colegios de Colombia portfolio CI