{"id":"zinc-oxide-eugenol-sealer","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reaction to eugenol"},{"rate":null,"effect":"Tissue irritation if extruded beyond apex"},{"rate":null,"effect":"Discoloration of tooth structure"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Zinc oxide reacts with eugenol to form zinc eugenolate, a hard, insoluble compound that provides mechanical sealing of the root canal. The material exhibits antimicrobial properties due to eugenol's phenolic nature and zinc's antimicrobial activity. This combination creates a biocompatible barrier that prevents bacterial recontamination and leakage of periapical fluids.","oneSentence":"Zinc-oxide eugenol sealer hardens and sets through a chelation reaction between zinc oxide and eugenol, forming a rigid matrix that seals the root canal system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:16:41.899Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Root canal obturation and sealing in endodontic therapy"}]},"trialDetails":[{"nctId":"NCT07343804","phase":"NA","title":"THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE","status":"RECRUITING","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2025-11-01","conditions":"Cardiovascular Disease Risk Factor, Periapical Periodontitis","enrollment":80},{"nctId":"NCT04885686","phase":"NA","title":"Endodontic Post-operative Pain Evaluation of Patients After Using Endomethasone N or Endomethasone SP (EndoPOP)","status":"COMPLETED","sponsor":"Septodont","startDate":"2021-06-22","conditions":"Root Canal Obturation","enrollment":300},{"nctId":"NCT06752889","phase":"NA","title":"Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars.","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-01-01","conditions":"Necrotic Pulp, Primary Teeth","enrollment":34},{"nctId":"NCT06482593","phase":"PHASE4","title":"Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement","status":"ACTIVE_NOT_RECRUITING","sponsor":"Institucion Universitaria Colegios de Colombia","startDate":"2023-08-01","conditions":"Apical Periodontitis","enrollment":72},{"nctId":"NCT06013293","phase":"NA","title":"Evaluation of Postoperative Pain With Resin Based Sealer vs Zinc Oxide Eugenol Based Sealer After Single Visit Endodontic","status":"UNKNOWN","sponsor":"Pakistan Institute of Medical Sciences","startDate":"2022-10-01","conditions":"Post Operative Pain","enrollment":100},{"nctId":"NCT04935736","phase":"NA","title":"Postoperative Pain After Root Canal Obturation With Sealer Containing Prednisolone.","status":"COMPLETED","sponsor":"ACTEON Group","startDate":"2021-06-30","conditions":"Root Canal Obturation","enrollment":243},{"nctId":"NCT04249206","phase":"PHASE4","title":"Outcome of Endodontic Treatment in Patient Treated With a Hydraulic Sealer","status":"UNKNOWN","sponsor":"Cittadella Universitaria","startDate":"2016-05-01","conditions":"Apical Periodontitis","enrollment":54},{"nctId":"NCT03874949","phase":"NA","title":"Pain After Root Canal Obturation With Sealer Containing or Not 1% Enoxolone","status":"COMPLETED","sponsor":"ACTEON Group","startDate":"2019-04-02","conditions":"Root Canal Obturation","enrollment":95},{"nctId":"NCT03397875","phase":"NA","title":"Effect of Various Sealers on Healing of Teeth With Apical Periodontitis","status":"COMPLETED","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2016-11","conditions":"Apical Periodontitis","enrollment":99},{"nctId":"NCT02630745","phase":"NA","title":"Immediate Verses Delayed Surgical Periodontal Therapy After Endodontic Treatment in Endo Perio Lesion With Communication","status":"COMPLETED","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2015-06","conditions":"Attachment Loss, Tooth,Non Vital","enrollment":40},{"nctId":"NCT01728532","phase":"NA","title":"Open, Multicentric Trial Evaluating the Efficacy and the Clinical Tolerance of PA0903 as Root Canal Sealer","status":"COMPLETED","sponsor":"Ascopharm Groupe Novasco","startDate":"2012-06","conditions":"Root Canal Obturation","enrollment":26},{"nctId":"NCT01312194","phase":"NA","title":"Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients","status":"COMPLETED","sponsor":"Universidade Federal do Rio de Janeiro","startDate":"2004-05","conditions":"Periapical Periodontitis","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":85,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Zinc-Oxide Eugenol Sealer","genericName":"Zinc-Oxide Eugenol Sealer","companyName":"Institucion Universitaria Colegios de Colombia","companyId":"institucion-universitaria-colegios-de-colombia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Zinc-oxide eugenol sealer hardens and sets through a chelation reaction between zinc oxide and eugenol, forming a rigid matrix that seals the root canal system. Used for Root canal obturation and sealing in endodontic therapy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}