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wasp venom
Wasp venom contains allergenic proteins that are used in allergen immunotherapy to desensitize patients to wasp stings by inducing immune tolerance.
Wasp venom contains allergenic proteins that are used in allergen immunotherapy to desensitize patients to wasp stings by inducing immune tolerance. Used for Wasp venom allergy with systemic reactions (prevention of anaphylaxis).
At a glance
| Generic name | wasp venom |
|---|---|
| Sponsor | Allergopharma GmbH & Co. KG |
| Drug class | Allergen immunotherapy |
| Modality | Biologic |
| Therapeutic area | Immunology / Allergy |
| Phase | FDA-approved |
Mechanism of action
Wasp venom immunotherapy (VIT) works by gradually exposing patients to increasing doses of wasp venom extract, which shifts the immune response from IgE-mediated (allergic) to IgG-mediated (protective) antibodies. This process induces regulatory T cells and reduces mast cell and basophil reactivity, thereby preventing anaphylaxis upon future wasp stings. The mechanism involves both immune tolerance induction and a reduction in allergen-specific IgE levels.
Approved indications
- Wasp venom allergy with systemic reactions (prevention of anaphylaxis)
Common side effects
- Local injection site reactions (swelling, erythema, pruritus)
- Systemic allergic reactions
- Anaphylaxis
- Angioedema
Key clinical trials
- Identification of B Regulatory Cells by Flow Cytometry
- Is the BAT Inhibition Able to Replace Sting Challenges? (BATIRS) (NA)
- Prospective Observational Study to Evaluate the Safety of Immunotherapy as a Treatment for Hymenoptera Venom Allergy
- Immunotherapy for the Treatment of Hymenoptera Venom Allergy in Real-life Conditions.
- Pilot Study: Characterization of the Immune Phenotype of Patients Allergic to Wasp Venom or Penicillin (NA)
- Diagnostic Accuracy of the MADx Multi Array Xplorer (MAX 45k) Automated Laboratory System and the MADx Allergy Explorer Version 2 (ALEX²) - IgE Multiplex Test for the Diagnosis of Pre-defined Groups of Specific High-priority Allergens (NA)
- Performance of CAST (Cellular Antigen Stimulation Test) in Patients With Wasp Venom Allergy: Evaluation of Neutralizing IgG Subclasses
- Efficacy and Safety of a Purified Standardised Wasp Venom Preparation (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- wasp venom CI brief — competitive landscape report
- wasp venom updates RSS · CI watch RSS
- Allergopharma GmbH & Co. KG portfolio CI