{"id":"wasp-venom","safety":{"commonSideEffects":[{"rate":"30-50","effect":"Local injection site reactions (swelling, erythema, pruritus)"},{"rate":"5-15","effect":"Systemic allergic reactions"},{"rate":"<1","effect":"Anaphylaxis"},{"rate":"1-5","effect":"Angioedema"}]},"_chembl":{"chemblId":"CHEMBL525408","moleculeType":"Protein","molecularWeight":"2027.38"},"_dailymed":{"setId":"e07e65c7-bbe0-4d45-a8d8-f98251644347","title":"HONEY BEE HYMENOPTERA VENOM VENOMIL DIAGNOSTIC KIT HONEY BEE HYMENOPTERA VENOM VENOMIL MAINTENANCE KIT WHITE FACED HORNET HYMENOPTERA VENOM VENOMIL DIAGNOSTIC KIT WHITE FACED HORNET HYMENOPTERA VENOM VENOMIL MAINTENANCE KIT YELLOW HORNET HYMENOPTERA VENOM VENOMIL DIAGNOSTIC KIT YELLOW HORNET HYMENOPTERA VENOM VENOMIL MAINTENANCE KIT WASP HYMENOPTERA VENOM VENOMIL DIAGNOSTIC KIT WASP HYMENOPTERA VENOM VENOMIL MAINTENANCE KIT YELLOW JACKET HYMENOPTERA VENOM VENOMIL DIAGNOSTIC KIT YELLOW JACKET HYMENOPTERA VENOM VENOMIL MAINTENANCE KIT MIXED VESPID HYMENOPTERA VENOM VENOMIL MAINTENANCE KIT [JUBILANT HOLLISTERSTIER LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Wasp venom immunotherapy (VIT) works by gradually exposing patients to increasing doses of wasp venom extract, which shifts the immune response from IgE-mediated (allergic) to IgG-mediated (protective) antibodies. This process induces regulatory T cells and reduces mast cell and basophil reactivity, thereby preventing anaphylaxis upon future wasp stings. The mechanism involves both immune tolerance induction and a reduction in allergen-specific IgE levels.","oneSentence":"Wasp venom contains allergenic proteins that are used in allergen immunotherapy to desensitize patients to wasp stings by inducing immune tolerance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:56.382Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wasp venom allergy with systemic reactions (prevention of anaphylaxis)"}]},"trialDetails":[{"nctId":"NCT06876506","phase":"","title":"Identification of B Regulatory Cells by Flow Cytometry","status":"NOT_YET_RECRUITING","sponsor":"Hull University Teaching Hospitals NHS Trust","startDate":"2026-02-01","conditions":"Pollen Allergy, Venom Allergy","enrollment":80},{"nctId":"NCT04438525","phase":"NA","title":"Is the BAT Inhibition Able to Replace Sting Challenges? (BATIRS)","status":"RECRUITING","sponsor":"Medical University of Graz","startDate":"2021-01-07","conditions":"Vespid Venom Allergy","enrollment":219},{"nctId":"NCT06782217","phase":"","title":"Prospective Observational Study to Evaluate the Safety of Immunotherapy as a Treatment for Hymenoptera Venom Allergy","status":"RECRUITING","sponsor":"Inmunotek S.L.","startDate":"2024-09-01","conditions":"Allergy, Insect Venom, Allergy Insect Stinging, Insect Sting Allergy","enrollment":120},{"nctId":"NCT06790368","phase":"","title":"Immunotherapy for the Treatment of Hymenoptera Venom Allergy in Real-life Conditions.","status":"RECRUITING","sponsor":"Inmunotek S.L.","startDate":"2025-01-01","conditions":"Allergy, Insect Venom, Allergy Insect Stinging, Insect Sting Allergy","enrollment":80},{"nctId":"NCT03219827","phase":"NA","title":"Pilot Study: Characterization of the Immune Phenotype of Patients Allergic to Wasp Venom or Penicillin","status":"COMPLETED","sponsor":"Institut Pasteur","startDate":"2017-06-13","conditions":"Allergy","enrollment":10},{"nctId":"NCT04435678","phase":"NA","title":"Diagnostic Accuracy of the MADx Multi Array Xplorer (MAX 45k) Automated Laboratory System and the MADx Allergy Explorer Version 2 (ALEX²) - IgE Multiplex Test for the Diagnosis of Pre-defined Groups of Specific High-priority Allergens","status":"COMPLETED","sponsor":"MacroArray Diagnostics GmbH","startDate":"2020-07-22","conditions":"Birch Pollen Allergy, Grass Pollen Allergy, House Dust Mite Allergy","enrollment":839},{"nctId":"NCT00794287","phase":"","title":"Performance of CAST (Cellular Antigen Stimulation Test) in Patients With Wasp Venom Allergy: Evaluation of Neutralizing IgG Subclasses","status":"WITHDRAWN","sponsor":"University of Zurich","startDate":"2009-01","conditions":"Wasp Venom Allergic Patients","enrollment":""},{"nctId":"NCT00263926","phase":"PHASE3","title":"Efficacy and Safety of a Purified Standardised Wasp Venom Preparation","status":"COMPLETED","sponsor":"Allergopharma GmbH & Co. KG","startDate":"2001-03","conditions":"Allergy","enrollment":""},{"nctId":"NCT00947908","phase":"NA","title":"Regulation of Blood Dendritic Cells During Immune Therapy for Hymenoptera Venom Allergy","status":"UNKNOWN","sponsor":"University of Rostock","startDate":"2009-06","conditions":"Hymenoptera Venom Allergy","enrollment":20}],"_emaApprovals":[],"_faersSignals":[{"count":3,"reaction":"HYPERSENSITIVITY"},{"count":2,"reaction":"ANAPHYLACTIC REACTION"},{"count":2,"reaction":"DRUG INTERACTION"},{"count":2,"reaction":"INJECTION SITE ERYTHEMA"},{"count":1,"reaction":"ANXIETY"},{"count":1,"reaction":"CHEST DISCOMFORT"},{"count":1,"reaction":"CONJUNCTIVAL HYPERAEMIA"},{"count":1,"reaction":"ERYTHEMA OF EYELID"},{"count":1,"reaction":"FLUSHING"},{"count":1,"reaction":"INJECTION SITE INDURATION"}],"_approvalHistory":[],"publicationCount":721,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"wasp venom","genericName":"wasp venom","companyName":"Allergopharma GmbH & Co. KG","companyId":"allergopharma-gmbh-co-kg","modality":"Biologic","firstApprovalDate":"","aiSummary":"Wasp venom contains allergenic proteins that are used in allergen immunotherapy to desensitize patients to wasp stings by inducing immune tolerance. Used for Wasp venom allergy with systemic reactions (prevention of anaphylaxis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}