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Vitamin D 2
Vitamin D 2 is a Vitamin D analog Small molecule drug developed by Department of Medical Services Ministry of Public Health of Thailand. It is currently in Phase 3 development for Rickets, Osteomalacia. Also known as: Ergocalciferol 300,000 IU.
Vitamin D 2 is a form of vitamin D that plays a crucial role in calcium absorption and bone health.
Vitamin D2, also known as doxercalciferol, is being studied in clinical trials for various conditions, including hyperparathyroidism, kidney failure, autism spectrum disorder, nonalcoholic steatohepatitis, and preterm infants. The exact mechanism of Vitamin D2 is not specified in the provided facts, but it is being compared to placebo and other interventions in clinical trials.
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Baseline phase 3 → approval rate
+58.3pp
Industry-wide phase 3 drugs reach approval ~58.3% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas).
| Regulator | Country | Likely year | Lag vs FDA |
|---|---|---|---|
| FDA | US | 2028–2030 | — |
| EMA | EU | 2029–2031 | +0.7 yr |
| MHRA | GB | 2029–2031 | +0.7 yr |
| Health Canada | CA | 2029–2032 | +0.9 yr |
| TGA | AU | 2029–2032 | +1.2 yr |
| PMDA | JP | 2029–2032 | +1.5 yr |
| NMPA | CN | 2030–2033 | +2.3 yr |
| MFDS | KR | 2029–2032 | +1.4 yr |
| CDSCO | IN | 2029–2033 | +1.8 yr |
| ANVISA | BR | 2030–2033 | +2.3 yr |
Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).
Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.
At a glance
| Generic name | Vitamin D 2 |
|---|---|
| Also known as | Ergocalciferol 300,000 IU |
| Sponsor | Department of Medical Services Ministry of Public Health of Thailand |
| Drug class | Vitamin D analog |
| Target | Vitamin D receptor |
| Modality | Small molecule |
| Therapeutic area | Endocrinology |
| Phase | Phase 3 |
Mechanism of action
Vitamin D 2 is a secosteroid that acts as a hormone in the body, regulating calcium levels and bone metabolism. It does this by binding to vitamin D receptors in the intestines, kidneys, and bones, which triggers the expression of genes involved in calcium absorption and bone mineralization.
Approved indications
- Rickets, Osteomalacia
Common side effects
- Hypercalcemia
Key clinical trials
- Toddler Biomarker of Nutrition Study (NA)
- Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma (PHASE3)
- Vitamin E Dosing Study (PHASE2)
- Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient Patients (PHASE2)
- Effect of the Consumption of Cookies Enriched With Plant Proteins and of a Vitamin D Supplement on the Progression of Sarcopenia in the Elderly (NA)
- Effects of Cofrogliptin on Beta-Cell Function in LADA Patients (NA)
- Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment (NA)
- Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vitamin D 2 CI brief — competitive landscape report
- Vitamin D 2 updates RSS · CI watch RSS
- Department of Medical Services Ministry of Public Health of Thailand portfolio CI
Frequently asked questions about Vitamin D 2
What is Vitamin D 2?
How does Vitamin D 2 work?
What is Vitamin D 2 used for?
Who makes Vitamin D 2?
Is Vitamin D 2 also known as anything else?
What drug class is Vitamin D 2 in?
What development phase is Vitamin D 2 in?
What are the side effects of Vitamin D 2?
What does Vitamin D 2 target?
Related
- Drug class: All Vitamin D analog drugs
- Target: All drugs targeting Vitamin D receptor
- Manufacturer: Department of Medical Services Ministry of Public Health of Thailand — full pipeline
- Therapeutic area: All drugs in Endocrinology
- Indication: Drugs for Rickets, Osteomalacia
- Also known as: Ergocalciferol 300,000 IU
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing