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Viral load driven treatment interruption
A treatment strategy that interrupts antiretroviral therapy based on viral load measurements to allow structured breaks in continuous HIV medication.
A treatment strategy that interrupts antiretroviral therapy based on viral load measurements to allow structured breaks in continuous HIV medication. Used for HIV-1 infection (treatment interruption strategy).
At a glance
| Generic name | Viral load driven treatment interruption |
|---|---|
| Sponsor | Hospital Clinic of Barcelona |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Viral load-driven treatment interruption (VDTI) is a therapeutic strategy rather than a drug itself, involving periodic cessation of antiretroviral therapy guided by CD4 count and viral load thresholds. The approach aims to reduce long-term medication exposure and associated toxicities while maintaining immune control through structured interruption cycles. This strategy was investigated primarily in the early-to-mid 2000s as an alternative to continuous antiretroviral therapy.
Approved indications
- HIV-1 infection (treatment interruption strategy)
Common side effects
- Viral rebound
- CD4 count decline
- Increased risk of opportunistic infections during interruption periods
- Cardiovascular events (associated with viral rebound)
Key clinical trials
- The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care (NA)
- Strategies of Interruption/Reinitiation of Antiretroviral Therapy in HIV-Infected Patients With Lipodystrophy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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