{"id":"viral-load-driven-treatment-interruption","safety":{"commonSideEffects":[{"rate":null,"effect":"Viral rebound"},{"rate":null,"effect":"CD4 count decline"},{"rate":null,"effect":"Increased risk of opportunistic infections during interruption periods"},{"rate":null,"effect":"Cardiovascular events (associated with viral rebound)"}]},"_chembl":{"chemblId":"CHEMBL2109000","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Viral load-driven treatment interruption (VDTI) is a therapeutic strategy rather than a drug itself, involving periodic cessation of antiretroviral therapy guided by CD4 count and viral load thresholds. The approach aims to reduce long-term medication exposure and associated toxicities while maintaining immune control through structured interruption cycles. This strategy was investigated primarily in the early-to-mid 2000s as an alternative to continuous antiretroviral therapy.","oneSentence":"A treatment strategy that interrupts antiretroviral therapy based on viral load measurements to allow structured breaks in continuous HIV medication.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:39:29.939Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV-1 infection (treatment interruption strategy)"}]},"trialDetails":[{"nctId":"NCT06554223","phase":"NA","title":"The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care","status":"RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2025-11-14","conditions":"Human Immunodeficiency Virus","enrollment":310},{"nctId":"NCT00646984","phase":"PHASE4","title":"Strategies of Interruption/Reinitiation of Antiretroviral Therapy in HIV-Infected Patients With Lipodystrophy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2002-01","conditions":"HIV-Associated Lipodystrophy Syndrome","enrollment":147}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Viral load driven treatment interruption","genericName":"Viral load driven treatment interruption","companyName":"Hospital Clinic of Barcelona","companyId":"hospital-clinic-of-barcelona","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A treatment strategy that interrupts antiretroviral therapy based on viral load measurements to allow structured breaks in continuous HIV medication. Used for HIV-1 infection (treatment interruption strategy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}