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venom immunotherapy
Venom immunotherapy desensitizes patients to insect venom by gradually introducing increasing doses of venom extract to build immune tolerance.
Venom immunotherapy desensitizes patients to insect venom by gradually introducing increasing doses of venom extract to build immune tolerance. Used for Hymenoptera (bee, wasp, hornet) venom allergy with systemic reactions, Prevention of anaphylaxis in patients with documented venom hypersensitivity.
At a glance
| Generic name | venom immunotherapy |
|---|---|
| Sponsor | Meir Medical Center |
| Drug class | Immunotherapy; desensitization therapy |
| Modality | Small molecule |
| Therapeutic area | Immunology; Allergy |
| Phase | FDA-approved |
Mechanism of action
The therapy works by administering gradually increasing concentrations of purified insect venom (typically from honeybees, wasps, or hornets) to induce immune tolerance. This process shifts the immune response from IgE-mediated hypersensitivity toward protective IgG antibodies and regulatory T cells, reducing the risk of anaphylaxis upon future stings. Maintenance therapy continues long-term to sustain this protective immunity.
Approved indications
- Hymenoptera (bee, wasp, hornet) venom allergy with systemic reactions
- Prevention of anaphylaxis in patients with documented venom hypersensitivity
Common side effects
- Local injection site reactions (swelling, erythema, pruritus)
- Systemic allergic reactions (urticaria, angioedema, bronchospasm)
- Anaphylaxis
- Headache
- Fatigue
Key clinical trials
- Predominant Sensitizations to Single Bee Venom Allergens as a Risk Factor for Therapy Failure
- Identification of B Regulatory Cells by Flow Cytometry
- Jack Jumper Ant Venom Immunotherapy Long-term Effectiveness Investigation (PHASE4)
- Is the BAT Inhibition Able to Replace Sting Challenges? (BATIRS) (NA)
- Hymenoptera Venom Immunotherapy: Evaluation of Its Long-term Efficacy at the University Hospital of Angers (EFLOTITA2)
- Interest of Flow Cytometry for the Diagnosis, the Follow up and Specific Immunotherapy (SIT) Arrest of Hymenoptera Venom Allergy (NA)
- Prospective Observational Study to Evaluate the Safety of Immunotherapy as a Treatment for Hymenoptera Venom Allergy
- Immunotherapy for the Treatment of Hymenoptera Venom Allergy in Real-life Conditions.
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- venom immunotherapy CI brief — competitive landscape report
- venom immunotherapy updates RSS · CI watch RSS
- Meir Medical Center portfolio CI