{"id":"venom-immunotherapy","safety":{"commonSideEffects":[{"rate":"40-80","effect":"Local injection site reactions (swelling, erythema, pruritus)"},{"rate":"5-15","effect":"Systemic allergic reactions (urticaria, angioedema, bronchospasm)"},{"rate":"0.1-1","effect":"Anaphylaxis"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL525408","moleculeType":"Protein","molecularWeight":"2027.38"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The therapy works by administering gradually increasing concentrations of purified insect venom (typically from honeybees, wasps, or hornets) to induce immune tolerance. This process shifts the immune response from IgE-mediated hypersensitivity toward protective IgG antibodies and regulatory T cells, reducing the risk of anaphylaxis upon future stings. Maintenance therapy continues long-term to sustain this protective immunity.","oneSentence":"Venom immunotherapy desensitizes patients to insect venom by gradually introducing increasing doses of venom extract to build immune tolerance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:15:06.868Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hymenoptera (bee, wasp, hornet) venom allergy with systemic reactions"},{"name":"Prevention of anaphylaxis in patients with documented venom hypersensitivity"}]},"trialDetails":[{"nctId":"NCT04259359","phase":"","title":"Predominant Sensitizations to Single Bee Venom Allergens as a Risk Factor for Therapy Failure","status":"RECRUITING","sponsor":"Medical University of Graz","startDate":"2019-05-02","conditions":"Bee Venom Allergy","enrollment":266},{"nctId":"NCT06876506","phase":"","title":"Identification of B Regulatory Cells by Flow Cytometry","status":"NOT_YET_RECRUITING","sponsor":"Hull University Teaching Hospitals NHS Trust","startDate":"2026-02-01","conditions":"Pollen Allergy, Venom Allergy","enrollment":80},{"nctId":"NCT06935890","phase":"PHASE4","title":"Jack Jumper Ant Venom Immunotherapy Long-term Effectiveness Investigation","status":"RECRUITING","sponsor":"Murdoch Childrens Research Institute","startDate":"2025-11-25","conditions":"Allergy, Immunotherapy, Venom Allergy","enrollment":100},{"nctId":"NCT04438525","phase":"NA","title":"Is the BAT Inhibition Able to Replace Sting Challenges? (BATIRS)","status":"RECRUITING","sponsor":"Medical University of Graz","startDate":"2021-01-07","conditions":"Vespid Venom Allergy","enrollment":219},{"nctId":"NCT05311644","phase":"","title":"Hymenoptera Venom Immunotherapy: Evaluation of Its Long-term Efficacy at the University Hospital of Angers (EFLOTITA2)","status":"COMPLETED","sponsor":"University Hospital, Angers","startDate":"2022-04-14","conditions":"Anaphylaxis Caused by Hymenoptera Venom (Disorder)","enrollment":290},{"nctId":"NCT00805402","phase":"NA","title":"Interest of Flow Cytometry for the Diagnosis, the Follow up and Specific Immunotherapy (SIT) Arrest of Hymenoptera Venom Allergy","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2008-07","conditions":"Allergy","enrollment":75},{"nctId":"NCT06782217","phase":"","title":"Prospective Observational Study to Evaluate the Safety of Immunotherapy as a Treatment for Hymenoptera Venom Allergy","status":"RECRUITING","sponsor":"Inmunotek S.L.","startDate":"2024-09-01","conditions":"Allergy, Insect Venom, Allergy Insect Stinging, Insect Sting Allergy","enrollment":120},{"nctId":"NCT06790368","phase":"","title":"Immunotherapy for the Treatment of Hymenoptera Venom Allergy in Real-life Conditions.","status":"RECRUITING","sponsor":"Inmunotek S.L.","startDate":"2025-01-01","conditions":"Allergy, Insect Venom, Allergy Insect Stinging, Insect Sting Allergy","enrollment":80},{"nctId":"NCT03219827","phase":"NA","title":"Pilot Study: Characterization of the Immune Phenotype of Patients Allergic to Wasp Venom or Penicillin","status":"COMPLETED","sponsor":"Institut Pasteur","startDate":"2017-06-13","conditions":"Allergy","enrollment":10},{"nctId":"NCT04269629","phase":"","title":"The Effect of Antihypertensive Drugs on Severity of Anaphylaxis and Side-effects During Venom Immunotherapy","status":"COMPLETED","sponsor":"Medical University of Graz","startDate":"2014-08","conditions":"Hymenoptera Venom Allergy, Antihypertensive Treatment","enrollment":1425},{"nctId":"NCT03066986","phase":"PHASE1, PHASE2","title":"Study of Sting Challenge and Serological Responses to Jack Jumper Venom Immunotherapy With Inulin as Adjuvant (Jumpvax)","status":"UNKNOWN","sponsor":"Central Adelaide Local Health Network Incorporated","startDate":"2016-10","conditions":"Ant Sting, Immunotherapy","enrollment":40},{"nctId":"NCT02931955","phase":"","title":"Applying Systems Immunology to the Search for Personalized Biomarkers of Clinical Efficacy","status":"COMPLETED","sponsor":"Luxembourg Institute of Health","startDate":"2016-08","conditions":"Allergy","enrollment":50},{"nctId":"NCT02295488","phase":"NA","title":"Determinism of the Mechanism of Action of Specific Immunotherapy in Hymenoptera Venom Allergy","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2015-03-23","conditions":"Hymenoptera Allergy","enrollment":29},{"nctId":"NCT02503800","phase":"","title":"The Significance of Blood-tryptase and c-Kit Mutation in Insect Venom Immunotherapy","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2015-08","conditions":"Hypersensitivity, Immediate, Insect Bites and Stings, Mastocytosis","enrollment":159},{"nctId":"NCT01666288","phase":"","title":"The Metabolomics of Anaphylaxis to Immunotherapy","status":"WITHDRAWN","sponsor":"Massachusetts General Hospital","startDate":"2012-04","conditions":"Anaphylaxis as a Result of Allergen or Venom Immunotherapy","enrollment":""},{"nctId":"NCT02968394","phase":"NA","title":"Omalizumab Treatment in Venom Immunotherapy With Systemic Reactions","status":"UNKNOWN","sponsor":"The University Clinic of Pulmonary and Allergic Diseases Golnik","startDate":"2014-03","conditions":"Allergy, Bee Venom, Immunotherapy","enrollment":11},{"nctId":"NCT00794287","phase":"","title":"Performance of CAST (Cellular Antigen Stimulation Test) in Patients With Wasp Venom Allergy: Evaluation of Neutralizing IgG Subclasses","status":"WITHDRAWN","sponsor":"University of Zurich","startDate":"2009-01","conditions":"Wasp Venom Allergic Patients","enrollment":""},{"nctId":"NCT00263926","phase":"PHASE3","title":"Efficacy and Safety of a Purified Standardised Wasp Venom Preparation","status":"COMPLETED","sponsor":"Allergopharma GmbH & Co. KG","startDate":"2001-03","conditions":"Allergy","enrollment":""},{"nctId":"NCT00263952","phase":"PHASE3","title":"Efficacy and Safety of a Purified Standardised Bee Venom Preparation","status":"COMPLETED","sponsor":"Allergopharma GmbH & Co. KG","startDate":"2003-03","conditions":"Bee Venom Allergy","enrollment":""},{"nctId":"NCT00684476","phase":"PHASE4","title":"Maintenance Bee-Venom Immunotherapy Administered at 6-Month Intervals Does Not Protect Against re-Stings","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2004-06","conditions":"Venom Allergy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":950,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"venom immunotherapy","genericName":"venom immunotherapy","companyName":"Meir Medical Center","companyId":"meir-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Venom immunotherapy desensitizes patients to insect venom by gradually introducing increasing doses of venom extract to build immune tolerance. Used for Hymenoptera (bee, wasp, hornet) venom allergy with systemic reactions, Prevention of anaphylaxis in patients with documented venom hypersensitivity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}