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Vaginal prostaglandin
Vaginal prostaglandins stimulate uterine contractions and cervical ripening to induce labor or facilitate pregnancy termination.
Vaginal prostaglandins stimulate uterine contractions and cervical ripening to induce labor or facilitate pregnancy termination. Used for Cervical ripening and labor induction, Medical abortion, Management of incomplete or missed miscarriage.
At a glance
| Generic name | Vaginal prostaglandin |
|---|---|
| Also known as | Vagiprost |
| Sponsor | Ain Shams University |
| Drug class | Prostaglandin analog |
| Target | Prostaglandin receptors (EP and FP receptors) |
| Modality | Small molecule |
| Therapeutic area | Obstetrics/Gynecology |
| Phase | Phase 3 |
Mechanism of action
Prostaglandins are naturally occurring lipid mediators that bind to prostaglandin receptors on uterine smooth muscle and cervical tissue. When administered vaginally, they promote myometrial contractions and cervical softening/dilation, making them effective for labor induction, cervical ripening, and medical abortion. The vaginal route provides sustained local delivery with systemic absorption.
Approved indications
- Cervical ripening and labor induction
- Medical abortion
- Management of incomplete or missed miscarriage
Common side effects
- Uterine hyperstimulation
- Vaginal bleeding
- Abdominal pain/cramping
- Nausea
- Diarrhea
- Fever
Key clinical trials
- Determination of Lipocalin Type-prostaglandin (L-PGDS) in Blood, Urine, Vaginal Samples and Endometrial Ablation by Enzyme-linked Immunosorbent Assay
- Improving Safe Vaginal Deliveries for Delivering Mothers by Implementing an Intervention Package of 11 Evidence-based Practices and Robson Classification at a Semi-urban Hospital in Dhaka, Bangladesh (NA)
- PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM) (NA)
- Carbetocin vs Misoprostol for Postpartum Hemorrhage Prevention (NA)
- Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies (PHASE3)
- Mechanical Dilation of the Cervix in a Scarred Uterus (NA)
- Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening (PHASE3)
- Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vaginal prostaglandin CI brief — competitive landscape report
- Vaginal prostaglandin updates RSS · CI watch RSS
- Ain Shams University portfolio CI