{"id":"vaginal-prostaglandin","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Vaginal bleeding"},{"rate":null,"effect":"Abdominal pain/cramping"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Prostaglandins are naturally occurring lipid mediators that bind to prostaglandin receptors on uterine smooth muscle and cervical tissue. When administered vaginally, they promote myometrial contractions and cervical softening/dilation, making them effective for labor induction, cervical ripening, and medical abortion. The vaginal route provides sustained local delivery with systemic absorption.","oneSentence":"Vaginal prostaglandins stimulate uterine contractions and cervical ripening to induce labor or facilitate pregnancy termination.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:54:34.042Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical ripening and labor induction"},{"name":"Medical abortion"},{"name":"Management of incomplete or missed miscarriage"}]},"trialDetails":[{"nctId":"NCT06864494","phase":"","title":"Determination of Lipocalin Type-prostaglandin (L-PGDS) in Blood, Urine, Vaginal Samples and Endometrial Ablation by Enzyme-linked Immunosorbent Assay","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2025-06-25","conditions":"Adenomyosis, Endometriosis","enrollment":60},{"nctId":"NCT07461571","phase":"NA","title":"Improving Safe Vaginal Deliveries for Delivering Mothers by Implementing an Intervention Package of 11 Evidence-based Practices and Robson Classification at a Semi-urban Hospital in Dhaka, Bangladesh","status":"COMPLETED","sponsor":"Ashulia Women and Children Hospital","startDate":"2017-06-01","conditions":"Caesarean Section","enrollment":2475},{"nctId":"NCT07366359","phase":"NA","title":"PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)","status":"RECRUITING","sponsor":"National Hospital of Obstetrics and Gynecology","startDate":"2026-02-10","conditions":"Premature Rupture of Fetal Membranes, Labor, Induced, Cervical Ripening","enrollment":450},{"nctId":"NCT07353281","phase":"NA","title":"Carbetocin vs Misoprostol for Postpartum Hemorrhage Prevention","status":"NOT_YET_RECRUITING","sponsor":"Western Galilee Hospital-Nahariya","startDate":"2026-01-31","conditions":"Postpartum Complication, Postpartum Hemorrhage","enrollment":146},{"nctId":"NCT02907060","phase":"PHASE3","title":"Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2017-01-27","conditions":"Prolonged Pregnancy","enrollment":1224},{"nctId":"NCT03471858","phase":"NA","title":"Mechanical Dilation of the Cervix in a Scarred Uterus","status":"COMPLETED","sponsor":"Ministry of Health, Singapore","startDate":"2019-08-29","conditions":"Pregnancy Related, Labor Complication, Cesarean Section; Dehiscence","enrollment":44},{"nctId":"NCT04949633","phase":"PHASE3","title":"Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening","status":"RECRUITING","sponsor":"University Hospital, Tours","startDate":"2021-09-28","conditions":"Cervical Ripening, Unfavorable Cervix","enrollment":1494},{"nctId":"NCT06803992","phase":"PHASE4","title":"Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter","status":"RECRUITING","sponsor":"HaEmek Medical Center, Israel","startDate":"2025-04-06","conditions":"Induction of Labor","enrollment":140},{"nctId":"NCT07160855","phase":"PHASE4","title":"Letrozole Plus Misoprostol Versus Misoprostol Alone for Treating Women With Missed Miscarriage","status":"RECRUITING","sponsor":"Nishtar Medical University","startDate":"2025-05-13","conditions":"Miscarriage in First Trimester, Missed Miscarriage","enrollment":92},{"nctId":"NCT00545194","phase":"PHASE3","title":"Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess","status":"WITHDRAWN","sponsor":"Institut National de la Santé Et de la Recherche Médicale, France","startDate":"2002-01","conditions":"Cervical Ripening, Labor, Induced","enrollment":""},{"nctId":"NCT07121634","phase":"NA","title":"Cervical Ripening With Misoprostol vs Isosorbide Mononitrate ; A Parallel -Arm Randomized Controlled Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Raid M. 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Baltimore","startDate":"2019-12-01","conditions":"Induction of Labor Affected Fetus / Newborn","enrollment":""},{"nctId":"NCT05079061","phase":"PHASE4","title":"A Trial of Sublingual Misoprostol to Reduce Primary Postpartum Haemorrhage After Vaginal Delivery","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2022-04","conditions":"Primary Postpartum Hemorrhage, Misoprostol, Delivery Complication","enrollment":1300},{"nctId":"NCT04500509","phase":"NA","title":"Diclofenac Potassium With or Without Vaginal Dinoprostone Prior to Hysterosalpingography","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"Infertility, Female","enrollment":200},{"nctId":"NCT05124314","phase":"PHASE4","title":"Comparison of Two Different Drug Regimens for Medical Treatment of Early Pregnancy Loss","status":"UNKNOWN","sponsor":"Clinical Hospital Merkur","startDate":"2021-10-27","conditions":"Abortion, 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Management of Atonic Postpartum Hemorrhage","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2019-04-01","conditions":"Postpartum Hemorrhage","enrollment":135},{"nctId":"NCT03870256","phase":"NA","title":"Oral Tranexamic Acid Plus Sublingual Misoprostol in Atonic Postpartum Hemorrhage","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2019-04-01","conditions":"Post Partum Hemorrhage","enrollment":135},{"nctId":"NCT03806231","phase":"PHASE3","title":"A Trial of Cervidil for Outpatient Pre-induction of Cervical Ripening","status":"TERMINATED","sponsor":"Intermountain Health Care, Inc.","startDate":"2019-08-07","conditions":"Induction of Labor Affected Fetus / Newborn","enrollment":8},{"nctId":"NCT05001061","phase":"EARLY_PHASE1","title":"Sublingual vs Vaginal Misoprostol for Termination of First Trimesteric Missed Abortion","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-08-03","conditions":"Missed Abortion","enrollment":288},{"nctId":"NCT04981457","phase":"PHASE1","title":"Comparative Study Between Combined Vaginal Misoprostol","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-03-02","conditions":"Missed Abortion","enrollment":60},{"nctId":"NCT03001661","phase":"PHASE3","title":"An RCT of a Synthetic Osmotic Cervical Dilator for Induction of Labour in Comparison to Dinoprostone Vaginal insErt","status":"COMPLETED","sponsor":"Birmingham Women's NHS Foundation Trust","startDate":"2017-12-19","conditions":"Induction of Labor Affected Fetus / Newborn","enrollment":674},{"nctId":"NCT03547778","phase":"PHASE4","title":"Misoprostol in Office Hysteroscopy and Endometrial Biopsy","status":"WITHDRAWN","sponsor":"University of South Florida","startDate":"2018-09-01","conditions":"Office Hysteroscopy and Endometrial Biopsy","enrollment":""},{"nctId":"NCT04887493","phase":"NA","title":"To Study the Efficacy and Safety of Misoprostol by Sublingual Routes for Induction of Labour","status":"UNKNOWN","sponsor":"Ministry of Health, Bhutan","startDate":"2021-06-01","conditions":"Induction of Labour","enrollment":500},{"nctId":"NCT04299854","phase":"","title":"Modality of Induction of Labor in Obese Women at Term (MODOBAT)","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Besancon","startDate":"2020-06-11","conditions":"Induction of Labor Affected Fetus / Newborn, Obese","enrollment":77},{"nctId":"NCT02957305","phase":"PHASE4","title":"Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2016-12-21","conditions":"Miscarriage in First Trimester","enrollment":211},{"nctId":"NCT03584698","phase":"PHASE4","title":"Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage","status":"COMPLETED","sponsor":"Assiut University","startDate":"2019-09-01","conditions":"Missed Abortion","enrollment":144},{"nctId":"NCT03067597","phase":"PHASE3","title":"An Open-label Trial Investigating the Efficacy and Safety of a Vaginal Insert in Pregnant Women at Term","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2017-02-22","conditions":"Cervical Ripening","enrollment":68},{"nctId":"NCT03111316","phase":"NA","title":"Foley Catheter Compared to the Foley Catheter Alone for Cervical Ripening","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2017-04-09","conditions":"Cervical Ripening, Induction of Labor","enrollment":100},{"nctId":"NCT04780412","phase":"PHASE3","title":"Efficacy of Misoprostol in Prevention of Neonatal Respiratory Morbidity in Parturient at Early Term Elective Caesarian Section","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2020-09-01","conditions":"Transient Tachypnea of the Newborn, Neonatal Respiratory Distress","enrollment":210},{"nctId":"NCT03976037","phase":"EARLY_PHASE1","title":"Buccal Versus Vaginal Misoprostol In Combination With Foley Bulb","status":"COMPLETED","sponsor":"Christiana Care Health Services","startDate":"2019-06-04","conditions":"Induction of Labor","enrollment":216},{"nctId":"NCT04743297","phase":"PHASE4","title":"Propess Versus Prostin for Induction of Labour in Women With Term PROM","status":"UNKNOWN","sponsor":"University Medical Centre Maribor","startDate":"2021-03","conditions":"Premature Rupture of Membranes at Term, Induction of Labour","enrollment":526},{"nctId":"NCT03682718","phase":"PHASE4","title":"Vaginal Misoprostol With Intracervical Foley Catheter in Induction of Labor","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2018-10-01","conditions":"Induction of Labor Affected Fetus / Newborn","enrollment":120},{"nctId":"NCT03067727","phase":"PHASE3","title":"A Randomised Trial Investigating the Efficacy and Safety of a Vaginal Insert in Pregnant Women at Term","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2017-04-03","conditions":"Cervical Ripening","enrollment":114},{"nctId":"NCT04595812","phase":"PHASE4","title":"Methods to Reduce Blood Loss in Abdominal Myomectomy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2020-11-01","conditions":"Abdominal Myomectomy, Blood Loss","enrollment":120},{"nctId":"NCT04593108","phase":"","title":"Misoprostol With or Without Letrozole in Treatment of Missed Miscarriage","status":"UNKNOWN","sponsor":"Dr.Dalia Mohammed Al Sayed Zaki","startDate":"2019-01-15","conditions":"Missed Abortion","enrollment":320},{"nctId":"NCT03033264","phase":"NA","title":"Labor Induction With Dinoprostone in Oppose to Cervical Ripening Balloon as a Factor of BMI.","status":"COMPLETED","sponsor":"Rambam Health Care Campus","startDate":"2017-01-01","conditions":"Induction of Labor","enrollment":164},{"nctId":"NCT04152317","phase":"PHASE3","title":"Dose Comparison of Misoprostol for Cervix Ripening Before Operative Hysteroscopy.","status":"COMPLETED","sponsor":"Professor Fernando Figueira Integral Medicine Institute","startDate":"2019-11-07","conditions":"Cervix; Open","enrollment":80},{"nctId":"NCT04536753","phase":"","title":"The Utility of Customised Growth Charts for Identifying Macrosomia and the Effect of Intervention","status":"COMPLETED","sponsor":"Newcastle University","startDate":"2018-01-01","conditions":"Obstetric Complication, Ultrasound, Induction of Labor Affected Fetus / Newborn","enrollment":845},{"nctId":"NCT02155725","phase":"PHASE4","title":"Fibrinogen in Haemorrhage of Delivery","status":"COMPLETED","sponsor":"Laboratoire français de Fractionnement et de Biotechnologies","startDate":"2014-04-10","conditions":"Post-Partum Hemorrhage","enrollment":448},{"nctId":"NCT04044079","phase":"PHASE4","title":"Vaginal Dinoprostone Versus Vaginal Misoprostol Prior to Diagnostic Office Hysteroscopy in Postmenopausal Patients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-08-20","conditions":"Office Hysteroscopy","enrollment":150},{"nctId":"NCT04080323","phase":"PHASE3","title":"Single-dose Vaginal Dinoprostone and Hysterectomy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-09-25","conditions":"Hysterectomy","enrollment":118},{"nctId":"NCT04505943","phase":"NA","title":"Vaginal Misoprostol and Dinoprostone and Isonicotinic Acid Hydrazide Prior to Copper Intrauterine Device Insertion","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"IUCD Complication","enrollment":200},{"nctId":"NCT04505917","phase":"NA","title":"Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Women","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"IUCD Complication","enrollment":200},{"nctId":"NCT04514770","phase":"NA","title":"Impact of Early Versus Late Amniotomy on Labour Induction in Nulliparous Women After Vaginal Misoprostol","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2019-05-03","conditions":"Labour Induction","enrollment":140},{"nctId":"NCT04500002","phase":"NA","title":"Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"IUCD Complication","enrollment":240},{"nctId":"NCT03708497","phase":"NA","title":"Carbetocin Versus Oral Tranexamic Acid Plus, Buccal Misoprostol on Blood Loss After Vaginal Delivery","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2018-12-01","conditions":"Postpartum Hemorrhage","enrollment":360},{"nctId":"NCT04499976","phase":"PHASE4","title":"Isonicotinic Acid Hydrazide Pretreatment With Misoprostol Induction of Abortion in First-trimester Missed Miscarriage","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"Abortion, Missed","enrollment":240},{"nctId":"NCT04079140","phase":"PHASE4","title":"Vaginal Dinoprostone Administration Prior to Intrauterine Device Insertion","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-09-15","conditions":"IUD Insertion Pain","enrollment":130},{"nctId":"NCT04280874","phase":"PHASE4","title":"Induction of Labor in Term Pregnancies With Unfavourable Cervix","status":"COMPLETED","sponsor":"Clinical Hospital Merkur","startDate":"2018-12-10","conditions":"Induction of Labor Affected Fetus / Newborn, Prostaglandins Causing Adverse Effects in Therapeutic Use","enrollment":212},{"nctId":"NCT03148561","phase":"NA","title":"Management of Women With an Incomplete Miscarriage","status":"COMPLETED","sponsor":"Assiut University","startDate":"2017-07-01","conditions":"Miscarriage","enrollment":84},{"nctId":"NCT04273984","phase":"PHASE4","title":"Efficacy and Safety of Different Doses of Vaginal Misoprostol 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